TY - JOUR
T1 - Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project
AU - The Study Group for Infections in Critically Ill Patients (ESGCIP)
AU - The Fungal Infection Study Group (EFISG) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
AU - the European Society of Intensive Care Medicine (ESICM)
AU - the European Confederation of Medical Mycology (ECMM)
AU - the Mycoses Study Group Education and Research Consortium (MSGERC)
AU - Bassetti, Matteo
AU - Scudeller, Luigia
AU - Giacobbe, Daniele R.
AU - Lamoth, Frederic
AU - Righi, Elda
AU - Zuccaro, Valentina
AU - Grecchi, Cecilia
AU - Rebuffi, Chiara
AU - Akova, Murat
AU - Alastruey-Izquierdo, Ana
AU - Arikan-Akdagli, Sevtap
AU - Azoulay, Elie
AU - Blot, Stijn I.
AU - Cornely, Oliver A.
AU - Lass-Flörl, Cornelia
AU - Koehler, Philipp
AU - Cuenca-Estrella, Manuel
AU - De Lange, Dylan W.
AU - De Rosa, Francesco G.
AU - De Waele, Jan J.
AU - Dimopoulos, George
AU - Garnacho-Montero, José
AU - Hoenigl, Martin
AU - Kanj, Souha S.
AU - Maertens, Johan
AU - Martin-Loeches, Ignacio
AU - Muñoz, Patricia
AU - Kullberg, Bart J.
AU - Agvald-Ohman, Christina
AU - Poulakou, Garyphallia
AU - Rello, Jordi
AU - Sanguinetti, Maurizio
AU - Taccone, Fabio S.
AU - Timsit, Jean François
AU - Torres, Antoni
AU - Vazquez, Jose A.
AU - Calandra, Thierry
N1 - Publisher Copyright:
© 2018 Blackwell Verlag GmbH.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU). Objectives: To develop a standard set of definitions for IFD in critically ill adult patients in ICU. Methods: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. The proposed definitions will be evaluated by a panel of 30 experts using the RAND/UCLA appropriateness methods. The panel will rank each of the proposed definitions on a 1-9 scale trough a dedicated questionnaire, in two rounds: one remote and one face-to- face. Based on their median rank and the level of agreement across panel members, selected definitions will be organised in a main consensus document and in an executive summary. The executive summary will be made available online for public comments. Conclusions: The present consensus project will seek to provide standard definitions for IFD in critically ill adult patients in ICU, with the ultimate aims of improving their clinical outcome and facilitating the comparison and generalizability of research findings.
AB - Background: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU). Objectives: To develop a standard set of definitions for IFD in critically ill adult patients in ICU. Methods: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. The proposed definitions will be evaluated by a panel of 30 experts using the RAND/UCLA appropriateness methods. The panel will rank each of the proposed definitions on a 1-9 scale trough a dedicated questionnaire, in two rounds: one remote and one face-to- face. Based on their median rank and the level of agreement across panel members, selected definitions will be organised in a main consensus document and in an executive summary. The executive summary will be made available online for public comments. Conclusions: The present consensus project will seek to provide standard definitions for IFD in critically ill adult patients in ICU, with the ultimate aims of improving their clinical outcome and facilitating the comparison and generalizability of research findings.
KW - Aspergillus
KW - Biomarker
KW - Candida
KW - Candidiasis
KW - Cryptococcosis
KW - Diagnosis
KW - Pneumocystosis
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U2 - 10.1111/myc.12869
DO - 10.1111/myc.12869
M3 - Article
C2 - 30426598
AN - SCOPUS:85059945689
SN - 0933-7407
VL - 62
SP - 310
EP - 319
JO - Mycoses
JF - Mycoses
IS - 4
ER -