Development of multiple organ dysfunction syndrome in older and young adult trauma patients

Objective: We sought out to determine the correlation between the injury severity score (ISS) and multiple organ dysfunction syndrome (MODS) between severely injured young adults (18–54 years) and elderly (>55 years) patients. Materials and Methods: This was a cross‑sectional observational study. We included all adult cases (>18 years) diagnosed with trauma defined by the International Classification of Diseases, Ninth Revision. For significance testing, Chi‑square test and odds ratio were used. Severe injuries were defined by an ISS >15. The presence of MODS was based on the definitions proposed by society for critical care medicine. Results: A total of 469 young and 173 elderly patients were included in the study. Among the 469 young adults, 193 had ISS >15, whereas out of the 173 elderly patients, 88 had an ISS >15. Severely injured young and elderly groups were more likely to develop MODS compared with those with an ISS <15 (P < 0.001 and P < 0.001, respectively). The elderly had a higher likelihood of developing MODS (P < 0.001; odds ratio: 5.17; 95% confidence interval: 2.74–9.80). Conclusion: This study demonstrated a direct relationship between an ISS >15 and the development of MODS. We also observed a five‑fold increase in the development of MODS among severely injured elderly patients.