TY - JOUR
T1 - Dietary Protein, Chronic Salt-Sensitive Hypertension, and Kidney Damage
AU - Mattson, David L.
AU - Dasinger, John Henry
AU - Abais-Battad, Justine M.
N1 - Publisher Copyright:
Copyright © 2023 The Author(s).
PY - 2023/8/1
Y1 - 2023/8/1
N2 - It has been estimated that over a fifth of deaths worldwide can be attributed to dietary risk factors. A particularly serious condition is salt-sensitive (SS) hypertension and renal damage, participants of which demonstrate increased morbidity and mortality. Notably, a large amount of evidence from humans and animals has demonstrated that other components of the diet can also modulate hypertension and associated end-organ damage. Evidence presented in this review provides support for the view that immunity and inflammation serve to amplify the development of SS hypertension and leads to malignant disease accompanied by tissue damage. Interestingly, SS hypertension is modulated by changes in dietary protein intake, which also influences immune mechanisms. Together, the evidence presented in this review from animal and human studies indicates that changes in dietary protein source have profound effects on the gut microbiota, microbiota-derived metabolites, gene expression, immune cell activation, the production of cytokines and other factors, and the development of SS hypertension and kidney damage.
AB - It has been estimated that over a fifth of deaths worldwide can be attributed to dietary risk factors. A particularly serious condition is salt-sensitive (SS) hypertension and renal damage, participants of which demonstrate increased morbidity and mortality. Notably, a large amount of evidence from humans and animals has demonstrated that other components of the diet can also modulate hypertension and associated end-organ damage. Evidence presented in this review provides support for the view that immunity and inflammation serve to amplify the development of SS hypertension and leads to malignant disease accompanied by tissue damage. Interestingly, SS hypertension is modulated by changes in dietary protein intake, which also influences immune mechanisms. Together, the evidence presented in this review from animal and human studies indicates that changes in dietary protein source have profound effects on the gut microbiota, microbiota-derived metabolites, gene expression, immune cell activation, the production of cytokines and other factors, and the development of SS hypertension and kidney damage.
KW - BP
KW - CKD
KW - immunology and pathology
KW - nutrition
KW - water-electrolyte balance
UR - http://www.scopus.com/inward/record.url?scp=85169501543&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85169501543&partnerID=8YFLogxK
U2 - 10.34067/KID.0000000000000210
DO - 10.34067/KID.0000000000000210
M3 - Review article
C2 - 37424061
AN - SCOPUS:85169501543
SN - 2641-7650
VL - 4
SP - 1181
EP - 1187
JO - Kidney360
JF - Kidney360
IS - 8
ER -