Differential effects of alkaloids on memory in rodents

Patrick M. Callahan, Alvin V. Terry, Manuel C. Peitsch, Julia Hoeng, Kyoko Koshibu

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Nicotinic acetylcholine receptors (nAChRs) play a critical role in the neuropharmacology of learning and memory. As such, naturally occurring alkaloids that regulate nAChR activity have gained interest for understanding and potentially improving memory function. In this study, we tested the acute effects of three known nicotinic alkaloids, nicotine, cotinine, and anatabine, in suppressing scopolamine-induced memory deficit in rodents by using two classic memory paradigms, Y-maze and novel object recognition (NOR) in mice and rats, respectively. We found that all compounds were able to suppress scopolamine-induced spatial memory deficit in the Y-maze spontaneous alternation paradigm. However, only nicotine was able to suppress the short-term object memory deficit in NOR, despite the higher doses of cotinine and anatabine used to account for their potential differences in nAChR activity. These results indicate that cotinine and anatabine can uniquely regulate short-term spatial memory, while nicotine seems to have more robust and general role in memory regulation in rodents. Thus, nAChR-activating alkaloids may possess distinct procognitive properties in rodents, depending on the memory types examined.

Original languageEnglish (US)
Article number9843
JournalScientific reports
Issue number1
StatePublished - Dec 2021
Externally publishedYes

ASJC Scopus subject areas

  • General


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