Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis involvement of G_iα2-linked Rho kinase activity

Medicine & Life Sciences

• sphingosine 1-phosphate 82%
• rho-Associated Kinases 78%
• Chemotaxis 68%
• Vascular Endothelial Growth Factor A 54%
• Endothelial Cells 47%
• Cell Movement 23%
• p38 Mitogen-Activated Protein Kinases 21%
• Sphingosine-1-Phosphate Receptors 19%
• Pulmonary Artery 12%
• Phosphotransferases 10%
• Myosin-Light-Chain Kinase 9%
• Y 27632 9%
• Exotoxins 9%
• Peptide Receptors 8%
• Hepatocyte Growth Factor 8%
• src-Family Kinases 8%
• Antisense Oligonucleotides 8%
• Pertussis Toxin 8%
• Chemotactic Factors 7%
• Angiogenesis Inducing Agents 7%
• Phosphatidylinositol 3-Kinase 7%
• GTP-Binding Proteins 7%
• Adrenergic Receptors 6%
• Endothelium 6%
• Transfection 6%
• Psychological Inhibition 5%
• Genes 5%
• Cattle 5%
• Blood Platelets 5%
• Amino Acids 4%
• Lipids 4%
• Peptides 4%
• Lung 3%
• Therapeutics 1%

Chemical Compounds

• Sphingosine 1-Phosphate 100%
• Angiogenic 31%
• Rho Kinase Inhibitor 19%
• G12 17%
• Protein 17%
• Exotoxin 16%
• Chemoattractant 15%
• P42 15%
• Antisense Oligonucleotide 14%
• Peptide 12%
• Toxin 10%
• Tyrosine 9%
• Modification 5%