TY - JOUR
T1 - Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD
AU - Cunningham, Kathryn A.
AU - Callahan, Patrick M.
AU - Appel, James B.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1985/1/22
Y1 - 1985/1/22
N2 - The stimulus properties of the serotonin precursor 1-5-hydroxytrptophan (5-HTP) and the hallucinogen d-lysergic acid diethylamide (LSD) were compared in a two-lever, water-reinforced drug discrimination task. 5-HTP (in combination with the peripheral decarboxylase inhibitor Ro 4-4602) elicited no more than 50% drug-lever responding in rats trained to discriminate LSD (0.08 mg/kg) from saline while LSD substituted completely in animals trained to discriminate 5-HTP (50 mg/kg) from saline. Combination tests indicated that, while the 5-HTP cue was unaffected by pretreatment with various serotonin antagonists, the substitution of LSD for 5-HTP was abolished by the putative serotonin-2 antagonist ketanserin. It was concluded that LSD mimics 5-HTP by stimulating a subset of serotonin receptors activated by 5-HTP which are sensitive to ketanserin (serotonin-2?).
AB - The stimulus properties of the serotonin precursor 1-5-hydroxytrptophan (5-HTP) and the hallucinogen d-lysergic acid diethylamide (LSD) were compared in a two-lever, water-reinforced drug discrimination task. 5-HTP (in combination with the peripheral decarboxylase inhibitor Ro 4-4602) elicited no more than 50% drug-lever responding in rats trained to discriminate LSD (0.08 mg/kg) from saline while LSD substituted completely in animals trained to discriminate 5-HTP (50 mg/kg) from saline. Combination tests indicated that, while the 5-HTP cue was unaffected by pretreatment with various serotonin antagonists, the substitution of LSD for 5-HTP was abolished by the putative serotonin-2 antagonist ketanserin. It was concluded that LSD mimics 5-HTP by stimulating a subset of serotonin receptors activated by 5-HTP which are sensitive to ketanserin (serotonin-2?).
KW - 1-5-Hydroxytryptophan
KW - Drug discrimination
KW - Serotonin (5-hydroxytryptamine)
KW - d-Lysergic acid diethylamide (LSD)
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U2 - 10.1016/0014-2999(85)90723-X
DO - 10.1016/0014-2999(85)90723-X
M3 - Article
C2 - 3156756
AN - SCOPUS:0021964089
SN - 0014-2999
VL - 108
SP - 179
EP - 186
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -