Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response

Keyphrases

• Inflammatory Response 100%
• Adiposity 100%
• Diet-induced 100%
• Adipose Tissue 100%
• Peripheral Insulin Resistance 100%
• 6-phosphofructo-2-kinase 100%
• PFKFB3 100%
• High-fat Diet 30%
• Littermate 30%
• Inflammatory Cytokines 20%
• Knockdown 20%
• Adipocyte 20%
• 3T3-L1 Adipocytes 20%
• Insulin Signaling 20%
• Adipose Tissue Dysfunction 20%
• Metabolic Disease 10%
• Reactive Oxygen Species Production 10%
• Type 2 Diabetes Mellitus (T2DM) 10%
• Insulin Sensitivity 10%
• Insulin Resistance 10%
• Lipids 10%
• Phosphorylation State 10%
• In Vitro System 10%
• Master Regulator 10%
• Undernutrition 10%
• Adipokines 10%
• Adipose Tissue Function 10%
• Adipose Tissue Macrophages 10%
• Nutrient Metabolism 10%
• Adipokine Expression 10%
• Adipocyte Lipolysis 10%

Biochemistry, Genetics and Molecular Biology

• Mouse 100%
• Insulin Resistance 100%
• 6-Phosphofructo-2-Kinase 100%
• Wild Type 80%
• Adipocyte 80%
• Proinflammatory Cytokine 40%
• Insulin Signaling 40%
• Adipokine 40%
• 3T3-L1 40%
• Metabolic Pathway 20%
• Body Weight 20%
• Lipid 20%
• Lipolysis 20%
• Insulin Sensitivity 20%
• Adipose Tissue Macrophages 20%

Immunology and Microbiology

• Inflammation Response 100%
• Insulin Resistance 100%
• Adipose Tissue 100%
• Mouse 83%
• Wild Type 66%
• Adipocyte 66%
• Proinflammatory Cytokine 33%
• Insulin Signaling 33%
• Adipokine 33%
• Insulin Sensitivity 16%
• Body Weight 16%
• Adipose Tissue Macrophages 16%
• Lipolysis 16%