Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma

Donn M. Stewart, Roshan Ramanathan, Siddhartha Mahanty, Daniel P. Fedorko, John Edward Janik, John C. Morris

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


A 55-year-old woman with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL) and a history of previously treated Strongyloides stercoralis infection received anti-CD52 monoclonal antibody therapy with alemtuzumab on a clinical trial. After an initial response, she developed ocular involvement by ATL. Alemtuzumab was stopped and high-dose corticosteroid therapy was started to palliate her ocular symptoms. Ten days later, the patient developed diarrhea, vomiting, fever, cough, skin rash, and a deteriorating mental status. She was diagnosed with disseminated S. stercoralis. Corticosteroids were discontinued and the patient received anthelmintic therapy with ivermectin and albendazole with complete clinical recovery.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalActa Haematologica
Issue number2
StatePublished - Aug 2011


  • Adult T-cell leukemia
  • Alemtuzumab
  • Corticosteroid
  • Disseminated Strongyloides
  • HTLV-1
  • Human T-cell lymphotropic virus type-1

ASJC Scopus subject areas

  • Hematology


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