DNA content of juvenile granulosa tumors determined by flow cytometry

Sven A. Swanson, Henry J. Norris, Martin L. Kelsten, James E. Wheeler

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Juvenile granulosa tumors (JGT) often exhibit worrisome morphologic features, yet usually behave in a benign fashion. Thirteen JGT were examined by flow cytometric analysis of paraffin material to determine if DNA content and cell kinetics are related to prognosis. The patients ranged in age from stillborn to 16 years. Unilateral salpingoophorectomy was the most common therapy. Eleven patients with follow-up were free of disease. Marked nuclear atypia was evident in three cases, and high mitotic counts were observed in six, but only marked atypia correlated with DNA content. Flow cytometry revealed that 46% of the JGT had abnormal DNA content and increased average growth fraction. The neoplasms with the highest DNA indices were found predominantly in postmenarchal girls. JGT may exhibit abnormal DNA content, nuclear atypia, and numerous mitoses, yet behave benignly. DNA flow cytometric studies of higher stage JGT are warranted.

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalInternational Journal of Gynecological Pathology
Issue number2
StatePublished - Apr 1990
Externally publishedYes


  • DNA content
  • Flow cytometry
  • Growth fraction
  • Juvenile granulosa tumor
  • Kinetics
  • Ovary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology


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