TY - JOUR
T1 - Dysregulation of microRNA and intracerebral hemorrhage
T2 - Roles in neuroinflammation
AU - Kashif, Hisham
AU - Shah, Dilan
AU - Sukumari-Ramesh, Sangeetha
N1 - Funding Information:
Funding: This work was supported by grants from the National Institutes of Health (R01NS107853) and American Heart Association (14SDG18730034) to S.S.-R.
Publisher Copyright:
© 2021 by the authors.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Intracerebral hemorrhage (ICH) is a major public health problem and devastating subtype of stroke with high morbidity and mortality. Notably, there is no effective treatment for ICH. Neuroinflammation, a pathological hallmark of ICH, contributes to both brain injury and repair and hence, it is regarded as a potential target for therapeutic intervention. Recent studies document that microRNAs, small non-coding RNA molecules, can regulate inflammatory brain response after ICH and are viable molecular targets to alter brain function. Therefore, there is an escalating interest in studying the role of microRNAs in the pathophysiology of ICH. Herein, we provide, for the first time, an overview of the microRNAs that play roles in ICH-induced neuroinflammation and identify the critical knowledge gap in the field, as it would help design future studies.
AB - Intracerebral hemorrhage (ICH) is a major public health problem and devastating subtype of stroke with high morbidity and mortality. Notably, there is no effective treatment for ICH. Neuroinflammation, a pathological hallmark of ICH, contributes to both brain injury and repair and hence, it is regarded as a potential target for therapeutic intervention. Recent studies document that microRNAs, small non-coding RNA molecules, can regulate inflammatory brain response after ICH and are viable molecular targets to alter brain function. Therefore, there is an escalating interest in studying the role of microRNAs in the pathophysiology of ICH. Herein, we provide, for the first time, an overview of the microRNAs that play roles in ICH-induced neuroinflammation and identify the critical knowledge gap in the field, as it would help design future studies.
KW - ICH
KW - MiR
KW - MicroRNA
KW - Neuroinflammation
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U2 - 10.3390/ijms22158115
DO - 10.3390/ijms22158115
M3 - Article
C2 - 34360881
AN - SCOPUS:85111675078
SN - 1661-6596
VL - 22
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 15
M1 - 8115
ER -
