Effect of a hydroxyapatite tricalcium phosphate alloplast on osseous repair in the rat calvarium

Kurt B. Fleckenstein; Michael F. Cuenin; Mark E. Peacock; Michael A. Billman; Gary D. Swiec; Thomas B. Buxton; Baldev B. Singh; James C. McPherson

doi:10.1902/jop.2006.77.1.39

Effect of a hydroxyapatite tricalcium phosphate alloplast on osseous repair in the rat calvarium

Kurt B. Fleckenstein, Michael F. Cuenin, Mark E. Peacock, Michael A. Billman, Gary D. Swiec, Thomas B. Buxton, Baldev B. Singh, James C. McPherson

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Background: Bony defects caused by periodontitis are often treated by regenerative therapy using autografts and/or allografts. Alloplasts, such as hydroxyapatite or ceramics, are also used as osteoconductive materials that serve as a scaffold for new bony ingrowth. The purpose of this study was to determine the effect of hydroxyapatite tricalcium phosphate (HA-TCP) on osseous repair in the rat calvarium. Methods: Forty-four adult male Harlan Sprague-Dawley rats were assigned to one of four treatment groups: HA-TCP macroporous disk, HA-TCP microporous disk, HA-TCP granules, and demineralized freeze-dried bone (DFDB). The materials were placed into 8-mm calvarial critical-size defects (CSD). Calvariae were harvested at 10 weeks post-surgery and evaluated histomorphometrically. Results: The DFDB group had significantly (P<0.05) more new bone formation (47%) than any other group. The HA-TCP macroporous disk group had significantly (P<0.05) more new bone formation (19.7%) than the HA-TCP microporous disk (8.5%) or HA-TCP granule (6.9%) groups. Conclusions: The HA-TCP macroporous disk may elicit significant new bone formation due to its rigid space-maintaining scaffold and pore size for vascular ingrowth. It is well tolerated by host tissues and may be a suitable carrier for growth factors.

Original language	English (US)
Pages (from-to)	39-45
Number of pages	7
Journal	Journal of periodontology
Volume	77
Issue number	1
DOIs	https://doi.org/10.1902/jop.2006.77.1.39
State	Published - Jan 1 2006
Externally published	Yes

Keywords

Animals
Bone
Grafts
Wound healing

ASJC Scopus subject areas

Periodontics

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10.1902/jop.2006.77.1.39

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title = "Effect of a hydroxyapatite tricalcium phosphate alloplast on osseous repair in the rat calvarium",

abstract = "Background: Bony defects caused by periodontitis are often treated by regenerative therapy using autografts and/or allografts. Alloplasts, such as hydroxyapatite or ceramics, are also used as osteoconductive materials that serve as a scaffold for new bony ingrowth. The purpose of this study was to determine the effect of hydroxyapatite tricalcium phosphate (HA-TCP) on osseous repair in the rat calvarium. Methods: Forty-four adult male Harlan Sprague-Dawley rats were assigned to one of four treatment groups: HA-TCP macroporous disk, HA-TCP microporous disk, HA-TCP granules, and demineralized freeze-dried bone (DFDB). The materials were placed into 8-mm calvarial critical-size defects (CSD). Calvariae were harvested at 10 weeks post-surgery and evaluated histomorphometrically. Results: The DFDB group had significantly (P<0.05) more new bone formation (47%) than any other group. The HA-TCP macroporous disk group had significantly (P<0.05) more new bone formation (19.7%) than the HA-TCP microporous disk (8.5%) or HA-TCP granule (6.9%) groups. Conclusions: The HA-TCP macroporous disk may elicit significant new bone formation due to its rigid space-maintaining scaffold and pore size for vascular ingrowth. It is well tolerated by host tissues and may be a suitable carrier for growth factors.",

keywords = "Animals, Bone, Grafts, Wound healing",

author = "Fleckenstein, {Kurt B.} and Cuenin, {Michael F.} and Peacock, {Mark E.} and Billman, {Michael A.} and Swiec, {Gary D.} and Buxton, {Thomas B.} and Singh, {Baldev B.} and McPherson, {James C.}",

year = "2006",

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doi = "10.1902/jop.2006.77.1.39",

language = "English (US)",

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T1 - Effect of a hydroxyapatite tricalcium phosphate alloplast on osseous repair in the rat calvarium

AU - Fleckenstein, Kurt B.

AU - Cuenin, Michael F.

AU - Peacock, Mark E.

AU - Billman, Michael A.

AU - Swiec, Gary D.

AU - Buxton, Thomas B.

AU - Singh, Baldev B.

AU - McPherson, James C.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Background: Bony defects caused by periodontitis are often treated by regenerative therapy using autografts and/or allografts. Alloplasts, such as hydroxyapatite or ceramics, are also used as osteoconductive materials that serve as a scaffold for new bony ingrowth. The purpose of this study was to determine the effect of hydroxyapatite tricalcium phosphate (HA-TCP) on osseous repair in the rat calvarium. Methods: Forty-four adult male Harlan Sprague-Dawley rats were assigned to one of four treatment groups: HA-TCP macroporous disk, HA-TCP microporous disk, HA-TCP granules, and demineralized freeze-dried bone (DFDB). The materials were placed into 8-mm calvarial critical-size defects (CSD). Calvariae were harvested at 10 weeks post-surgery and evaluated histomorphometrically. Results: The DFDB group had significantly (P<0.05) more new bone formation (47%) than any other group. The HA-TCP macroporous disk group had significantly (P<0.05) more new bone formation (19.7%) than the HA-TCP microporous disk (8.5%) or HA-TCP granule (6.9%) groups. Conclusions: The HA-TCP macroporous disk may elicit significant new bone formation due to its rigid space-maintaining scaffold and pore size for vascular ingrowth. It is well tolerated by host tissues and may be a suitable carrier for growth factors.

AB - Background: Bony defects caused by periodontitis are often treated by regenerative therapy using autografts and/or allografts. Alloplasts, such as hydroxyapatite or ceramics, are also used as osteoconductive materials that serve as a scaffold for new bony ingrowth. The purpose of this study was to determine the effect of hydroxyapatite tricalcium phosphate (HA-TCP) on osseous repair in the rat calvarium. Methods: Forty-four adult male Harlan Sprague-Dawley rats were assigned to one of four treatment groups: HA-TCP macroporous disk, HA-TCP microporous disk, HA-TCP granules, and demineralized freeze-dried bone (DFDB). The materials were placed into 8-mm calvarial critical-size defects (CSD). Calvariae were harvested at 10 weeks post-surgery and evaluated histomorphometrically. Results: The DFDB group had significantly (P<0.05) more new bone formation (47%) than any other group. The HA-TCP macroporous disk group had significantly (P<0.05) more new bone formation (19.7%) than the HA-TCP microporous disk (8.5%) or HA-TCP granule (6.9%) groups. Conclusions: The HA-TCP macroporous disk may elicit significant new bone formation due to its rigid space-maintaining scaffold and pore size for vascular ingrowth. It is well tolerated by host tissues and may be a suitable carrier for growth factors.

KW - Animals

KW - Bone

KW - Grafts

KW - Wound healing

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Effect of a hydroxyapatite tricalcium phosphate alloplast on osseous repair in the rat calvarium

Abstract

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