TY - JOUR
T1 - Effect of a new calcium antagonist on hemodynamics at rest and exercise loading in patients with essential hypertension
AU - Suzuki, S.
AU - Hashimoto, T.
AU - Kusano, S.
AU - Kapuku, Kakota Gaston
AU - Utsunomiya, T.
AU - Yano, K.
PY - 1993
Y1 - 1993
N2 - MPC-1304 ((±)-methyl 2-oxopropyl 1,4-dihydro 2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate, CAS 86780-90-7), a new calcium antagonist, was orally administered to 10 outpatients with mild essential hypertension. It was observed that MPC-1304 inhibited elevations of blood pressure both at rest and under exercise loading without any adverse hemodynamie effects. The findings obtained indicated that MPC-1304 would be clinically useful in the treatment of hypertensive patients undergoing therapy while continuing normal everyday activities including physical exertion.
AB - MPC-1304 ((±)-methyl 2-oxopropyl 1,4-dihydro 2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate, CAS 86780-90-7), a new calcium antagonist, was orally administered to 10 outpatients with mild essential hypertension. It was observed that MPC-1304 inhibited elevations of blood pressure both at rest and under exercise loading without any adverse hemodynamie effects. The findings obtained indicated that MPC-1304 would be clinically useful in the treatment of hypertensive patients undergoing therapy while continuing normal everyday activities including physical exertion.
KW - (±)-methyl 2-oxopropyl 1,4-dihydro 2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate
KW - CAS 86780-90-7
KW - MPC-1304
KW - antihypertensives
KW - hypertension, essential
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M3 - Article
C2 - 8292057
AN - SCOPUS:0027422072
SN - 0004-4172
VL - 43
SP - 1152
EP - 1156
JO - Arzneimittel-Forschung/Drug Research
JF - Arzneimittel-Forschung/Drug Research
IS - 11
ER -