Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder

Nathan A. Kimbrel; Melanie E. Garrett; Michelle F. Dennis; Yutao Liu; Ilyas Patanam; Allison E. Ashley-Koch; Michael A. Hauser; Jean C. Beckham; John Mason; Marinell Miller-Mumford; Scott D. McDonald; Treven Pickett; Robin A. Hurley; Jared Rowland; Katherine H. Taber; Ruth E. Yoash-Gantz; Mira Brancu; Patrick S. Calhoun; Eric A. Dedert; Eric B. Elbogen; John A. Fairbank; Kimberly T. Green; Jason D. Kilts; Angela C. Kirby; Christine E. Marx; Gregory McCarthy; Scott D. Moore; Rajendra A. Morey; Jennifer Naylor; Jennifer J. Runnals; Steven T. Szabo; Kristy A. Straits-Tröster; Larry A. Tupler; Elizabeth E. Van Voorhees; Ryan H. Wagner; Richard D. Weiner; Mid-Atlantic MIRECC Workgroup VA Mid-Atlantic MIRECC Workgroup

doi:10.1016/j.psychres.2015.07.002

Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder

Nathan A. Kimbrel, Melanie E. Garrett, Michelle F. Dennis, Yutao Liu, Ilyas Patanam, Allison E. Ashley-Koch, Michael A. Hauser, Jean C. Beckham, John Mason, Marinell Miller-Mumford, Scott D. McDonald, Treven Pickett, Robin A. Hurley, Jared Rowland, Katherine H. Taber, Ruth E. Yoash-Gantz, Mira Brancu, Patrick S. Calhoun, Eric A. Dedert, Eric B. ElbogenJohn A. Fairbank, Kimberly T. Green, Jason D. Kilts, Angela C. Kirby, Christine E. Marx, Gregory McCarthy, Scott D. Moore, Rajendra A. Morey, Jennifer Naylor, Jennifer J. Runnals, Steven T. Szabo, Kristy A. Straits-Tröster, Larry A. Tupler, Elizabeth E. Van Voorhees, Ryan H. Wagner, Richard D. Weiner, Mid-Atlantic MIRECC Workgroup VA Mid-Atlantic MIRECC Workgroup

Cellular Biology and Anatomy

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The present study examined the association between genetic variation in the nicotinic receptor gene family (. CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD). Clinical interviews were used to diagnose PTSD in 925 non-Hispanic Black (NHB) and 743 non-Hispanic White (NHW) participants. Trauma history and smoking status were assessed with self-report. No significant main effects or single nucleotide polymorphism (SNP) smoking interactions were observed among NHB participants; however, among NHW participants, a novel association between rs12898919 in the cholinergic receptor nicotinic alpha-5 (CHRNA5) gene and PTSD was observed. No other significant main effects or SNP * smoking interactions were identified among NHW participants. While preliminary, these findings provide continued support for the hypothesis that the CHRNA5 gene is associated with increased risk for PTSD. Limitations of the present study include cross-sectional design, relatively small sample sizes for genetic research, use of self-report to assess smoking status, and use of different methods to diagnose PTSD. Additional research in other samples of trauma-exposed participants is needed to identify the specific functional variant(s) responsible for the association observed between CHRNA5 and PTSD risk in the present study.

Original language	English (US)
Pages (from-to)	326-331
Number of pages	6
Journal	Psychiatry Research
Volume	229
Issue number	1-2
DOIs	https://doi.org/10.1016/j.psychres.2015.07.002
State	Published - Sep 30 2015

Keywords

Gene
Genetic
Nicotine
PTSD
Posttraumatic stress disorder
Smoking
Trauma

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2015.07.002

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Kimbrel, N. A., Garrett, M. E., Dennis, M. F., Liu, Y., Patanam, I., Ashley-Koch, A. E., Hauser, M. A., Beckham, J. C., Mason, J., Miller-Mumford, M., McDonald, S. D., Pickett, T., Hurley, R. A., Rowland, J., Taber, K. H., Yoash-Gantz, R. E., Brancu, M., Calhoun, P. S., Dedert, E. A., ... VA Mid-Atlantic MIRECC Workgroup, M.-A. MIRECC. W. (2015). Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. Psychiatry Research, 229(1-2), 326-331. https://doi.org/10.1016/j.psychres.2015.07.002

Kimbrel, NA, Garrett, ME, Dennis, MF, Liu, Y, Patanam, I, Ashley-Koch, AE, Hauser, MA, Beckham, JC, Mason, J, Miller-Mumford, M, McDonald, SD, Pickett, T, Hurley, RA, Rowland, J, Taber, KH, Yoash-Gantz, RE, Brancu, M, Calhoun, PS, Dedert, EA, Elbogen, EB, Fairbank, JA, Green, KT, Kilts, JD, Kirby, AC, Marx, CE, McCarthy, G, Moore, SD, Morey, RA, Naylor, J, Runnals, JJ, Szabo, ST, Straits-Tröster, KA, Tupler, LA, Van Voorhees, EE, Wagner, RH, Weiner, RD & VA Mid-Atlantic MIRECC Workgroup, M-AMIRECCW 2015, 'Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder', Psychiatry Research, vol. 229, no. 1-2, pp. 326-331. https://doi.org/10.1016/j.psychres.2015.07.002

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title = "Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder",

abstract = "The present study examined the association between genetic variation in the nicotinic receptor gene family (. CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD). Clinical interviews were used to diagnose PTSD in 925 non-Hispanic Black (NHB) and 743 non-Hispanic White (NHW) participants. Trauma history and smoking status were assessed with self-report. No significant main effects or single nucleotide polymorphism (SNP) smoking interactions were observed among NHB participants; however, among NHW participants, a novel association between rs12898919 in the cholinergic receptor nicotinic alpha-5 (CHRNA5) gene and PTSD was observed. No other significant main effects or SNP * smoking interactions were identified among NHW participants. While preliminary, these findings provide continued support for the hypothesis that the CHRNA5 gene is associated with increased risk for PTSD. Limitations of the present study include cross-sectional design, relatively small sample sizes for genetic research, use of self-report to assess smoking status, and use of different methods to diagnose PTSD. Additional research in other samples of trauma-exposed participants is needed to identify the specific functional variant(s) responsible for the association observed between CHRNA5 and PTSD risk in the present study.",

keywords = "Gene, Genetic, Nicotine, PTSD, Posttraumatic stress disorder, Smoking, Trauma",

author = "Kimbrel, {Nathan A.} and Garrett, {Melanie E.} and Dennis, {Michelle F.} and Yutao Liu and Ilyas Patanam and Ashley-Koch, {Allison E.} and Hauser, {Michael A.} and Beckham, {Jean C.} and John Mason and Marinell Miller-Mumford and McDonald, {Scott D.} and Treven Pickett and Hurley, {Robin A.} and Jared Rowland and Taber, {Katherine H.} and Yoash-Gantz, {Ruth E.} and Mira Brancu and Calhoun, {Patrick S.} and Dedert, {Eric A.} and Elbogen, {Eric B.} and Fairbank, {John A.} and Green, {Kimberly T.} and Kilts, {Jason D.} and Kirby, {Angela C.} and Marx, {Christine E.} and Gregory McCarthy and Moore, {Scott D.} and Morey, {Rajendra A.} and Jennifer Naylor and Runnals, {Jennifer J.} and Szabo, {Steven T.} and Straits-Tr{\"o}ster, {Kristy A.} and Tupler, {Larry A.} and {Van Voorhees}, {Elizabeth E.} and Wagner, {Ryan H.} and Weiner, {Richard D.} and {VA Mid-Atlantic MIRECC Workgroup}, {Mid-Atlantic MIRECC Workgroup}",

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year = "2015",

month = sep,

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doi = "10.1016/j.psychres.2015.07.002",

language = "English (US)",

volume = "229",

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journal = "Psychiatry Research",

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T1 - Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder

AU - Kimbrel, Nathan A.

AU - Garrett, Melanie E.

AU - Dennis, Michelle F.

AU - Liu, Yutao

AU - Patanam, Ilyas

AU - Ashley-Koch, Allison E.

AU - Hauser, Michael A.

AU - Beckham, Jean C.

AU - Mason, John

AU - Miller-Mumford, Marinell

AU - McDonald, Scott D.

AU - Pickett, Treven

AU - Hurley, Robin A.

AU - Rowland, Jared

AU - Taber, Katherine H.

AU - Yoash-Gantz, Ruth E.

AU - Brancu, Mira

AU - Calhoun, Patrick S.

AU - Dedert, Eric A.

AU - Elbogen, Eric B.

AU - Fairbank, John A.

AU - Green, Kimberly T.

AU - Kilts, Jason D.

AU - Kirby, Angela C.

AU - Marx, Christine E.

AU - McCarthy, Gregory

AU - Moore, Scott D.

AU - Morey, Rajendra A.

AU - Naylor, Jennifer

AU - Runnals, Jennifer J.

AU - Szabo, Steven T.

AU - Straits-Tröster, Kristy A.

AU - Tupler, Larry A.

AU - Van Voorhees, Elizabeth E.

AU - Wagner, Ryan H.

AU - Weiner, Richard D.

AU - VA Mid-Atlantic MIRECC Workgroup, Mid-Atlantic MIRECC Workgroup

PY - 2015/9/30

Y1 - 2015/9/30

N2 - The present study examined the association between genetic variation in the nicotinic receptor gene family (. CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD). Clinical interviews were used to diagnose PTSD in 925 non-Hispanic Black (NHB) and 743 non-Hispanic White (NHW) participants. Trauma history and smoking status were assessed with self-report. No significant main effects or single nucleotide polymorphism (SNP) smoking interactions were observed among NHB participants; however, among NHW participants, a novel association between rs12898919 in the cholinergic receptor nicotinic alpha-5 (CHRNA5) gene and PTSD was observed. No other significant main effects or SNP * smoking interactions were identified among NHW participants. While preliminary, these findings provide continued support for the hypothesis that the CHRNA5 gene is associated with increased risk for PTSD. Limitations of the present study include cross-sectional design, relatively small sample sizes for genetic research, use of self-report to assess smoking status, and use of different methods to diagnose PTSD. Additional research in other samples of trauma-exposed participants is needed to identify the specific functional variant(s) responsible for the association observed between CHRNA5 and PTSD risk in the present study.

AB - The present study examined the association between genetic variation in the nicotinic receptor gene family (. CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD). Clinical interviews were used to diagnose PTSD in 925 non-Hispanic Black (NHB) and 743 non-Hispanic White (NHW) participants. Trauma history and smoking status were assessed with self-report. No significant main effects or single nucleotide polymorphism (SNP) smoking interactions were observed among NHB participants; however, among NHW participants, a novel association between rs12898919 in the cholinergic receptor nicotinic alpha-5 (CHRNA5) gene and PTSD was observed. No other significant main effects or SNP * smoking interactions were identified among NHW participants. While preliminary, these findings provide continued support for the hypothesis that the CHRNA5 gene is associated with increased risk for PTSD. Limitations of the present study include cross-sectional design, relatively small sample sizes for genetic research, use of self-report to assess smoking status, and use of different methods to diagnose PTSD. Additional research in other samples of trauma-exposed participants is needed to identify the specific functional variant(s) responsible for the association observed between CHRNA5 and PTSD risk in the present study.

KW - Gene

KW - Genetic

KW - Nicotine

KW - PTSD

KW - Posttraumatic stress disorder

KW - Smoking

KW - Trauma

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ER -

Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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