TY - JOUR
T1 - Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS
AU - Goss, Amy M.
AU - Chandler-Laney, Paula C.
AU - Ovalle, Fernando
AU - Goree, Laura Lee
AU - Azziz, Ricardo
AU - Desmond, Renee A.
AU - Wright Bates, G.
AU - Gower, Barbara A.
N1 - Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Objective To determine if consumption of a reduced-carbohydrate (CHO) diet would result in preferential loss of adipose tissue under eucaloric conditions, and whether changes in adiposity were associated with changes in postprandial insulin concentration.Methods In a crossover-diet intervention, 30 women with PCOS consumed a reduced-CHO diet (41:19:40% energy from CHO:protein:fat) for 8 weeks and a standard diet (55:18:27) for 8 weeks. Body composition by DXA and fat distribution by CT were assessed at baseline and following each diet phase. Insulin AUC was obtained from a solid meal test (SMT) during each diet phase.Results Participants lost 3.7% and 2.2% total fat following the reduced-CHO diet and STD diet, resp. (p < 0.05 for difference between diets). The reduced-CHO diet induced a decrease in subcutaneous-abdominal, intra-abdominal, and thigh-intermuscular adipose tissue (- 7.1%, - 4.6%, and - 11.5%, resp.), and the STD diet induced a decrease in total lean mass. Loss of fat mass following the reduced CHO diet arm was associated with lower insulin AUC (p < 0.05) during the SMT.Conclusions In women with PCOS, consumption of a diet lower in CHO resulted in preferential loss of fat mass from metabolically harmful adipose depots, whereas a diet high in CHO appeared to promote repartitioning of lean mass to fat mass.
AB - Objective To determine if consumption of a reduced-carbohydrate (CHO) diet would result in preferential loss of adipose tissue under eucaloric conditions, and whether changes in adiposity were associated with changes in postprandial insulin concentration.Methods In a crossover-diet intervention, 30 women with PCOS consumed a reduced-CHO diet (41:19:40% energy from CHO:protein:fat) for 8 weeks and a standard diet (55:18:27) for 8 weeks. Body composition by DXA and fat distribution by CT were assessed at baseline and following each diet phase. Insulin AUC was obtained from a solid meal test (SMT) during each diet phase.Results Participants lost 3.7% and 2.2% total fat following the reduced-CHO diet and STD diet, resp. (p < 0.05 for difference between diets). The reduced-CHO diet induced a decrease in subcutaneous-abdominal, intra-abdominal, and thigh-intermuscular adipose tissue (- 7.1%, - 4.6%, and - 11.5%, resp.), and the STD diet induced a decrease in total lean mass. Loss of fat mass following the reduced CHO diet arm was associated with lower insulin AUC (p < 0.05) during the SMT.Conclusions In women with PCOS, consumption of a diet lower in CHO resulted in preferential loss of fat mass from metabolically harmful adipose depots, whereas a diet high in CHO appeared to promote repartitioning of lean mass to fat mass.
KW - Intra-abdominal adipose tissue
KW - Macronutrient composition
KW - Obesity
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U2 - 10.1016/j.metabol.2014.07.007
DO - 10.1016/j.metabol.2014.07.007
M3 - Article
C2 - 25125349
AN - SCOPUS:84908253446
SN - 0026-0495
VL - 63
SP - 1257
EP - 1264
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 10
ER -
