Effects of environmental enrichment on gene expression in the brain

Claire Rampon; Cecilia H. Jiang; Helin Dong; Ya Ping Tang; David J. Lockhart; Peter G. Schultz; Joseph Zhuo Tsien; Yinghe Hu

doi:10.1073/pnas.97.23.12880

Effects of environmental enrichment on gene expression in the brain

Claire Rampon, Cecilia H. Jiang, Helin Dong, Ya Ping Tang, David J. Lockhart, Peter G. Schultz, Joseph Zhuo Tsien, Yinghe Hu

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Abstract

An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 305-307]. To better understand the molecular mechanisms underlying these experience-dependent cognitive changes, we have used high-density oligonucleotide microarrays to analyze gene expression in the brain. Expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal structure, synaptic plasticity, and transmission. A number of these genes may play important roles in modulating learning and memory capacity.

Original language	English (US)
Pages (from-to)	12880-12884
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	97
Issue number	23
DOIs	https://doi.org/10.1073/pnas.97.23.12880
State	Published - Nov 7 2000
Externally published	Yes

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AU - Tang, Ya Ping

AU - Lockhart, David J.

AU - Schultz, Peter G.

AU - Tsien, Joseph Zhuo

AU - Hu, Yinghe

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AB - An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 305-307]. To better understand the molecular mechanisms underlying these experience-dependent cognitive changes, we have used high-density oligonucleotide microarrays to analyze gene expression in the brain. Expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal structure, synaptic plasticity, and transmission. A number of these genes may play important roles in modulating learning and memory capacity.

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Effects of environmental enrichment on gene expression in the brain

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