TY - JOUR
T1 - Effects of Mycobacterium avium complex-infection treatment on cytokine expression in human immunodeficiency virus-infected persons
T2 - Results of AIDS Clinical Trials Group Protocol 853
AU - MacArthur, Rodger D.
AU - Lederman, Michael M.
AU - Benson, Constance A.
AU - Chernoff, Miriam C.
AU - MacGregor, Rob Roy
AU - Spritzler, John
AU - Mahon, Laura F.
AU - Yen-Lieberman, Belinda
AU - Purvis, Scott
N1 - Funding Information:
Received 15 July 1999; revised 13 December 1999; electronically published 13 April 2000. Presented in part: 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, California, 24–27 September 1998 (abstract I130). Informed consent was obtained from all participants. Financial support: award AI 38858 and a grant from Abbott Laboratories (M.M.L.). Reprints or correspondence: Dr. Rodger D. MacArthur, 4201 St. Antoine, UHC 7D, Detroit, MI 48201 (macarthur@intmed.wayne.edu).
PY - 2000
Y1 - 2000
N2 - Human immunodeficiency virus (HIV) type 1-infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8- week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens were obtained for quantitative MAC cultures and to determine plasma levels of HIV RNA, TNF-α, and other proinflammatory cytokines. MAC levels decreased by 1.75 log at week 4 (P = .008) and by 2.48 log at week 8 (P = .001). Plasma TNF-α decreased by 0.15 log at week 4 (P = .042) and by 0.40 log at week 8 (P = .027). Plasma interleukin (IL)-6 decreased by 0.56 log at week 8 (P = .039). There were nonsignificant trends (P < .10) for plasma levels of IL-1β and HIV RNA to decrease at week 8. Nonsignificant decreases in plasma levels of TNF-α, IL-1β, ID-6, and HIV RNA were also seen in those individuals who remained on stable antiretroviral therapy throughout the 8 weeks of the study.
AB - Human immunodeficiency virus (HIV) type 1-infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8- week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens were obtained for quantitative MAC cultures and to determine plasma levels of HIV RNA, TNF-α, and other proinflammatory cytokines. MAC levels decreased by 1.75 log at week 4 (P = .008) and by 2.48 log at week 8 (P = .001). Plasma TNF-α decreased by 0.15 log at week 4 (P = .042) and by 0.40 log at week 8 (P = .027). Plasma interleukin (IL)-6 decreased by 0.56 log at week 8 (P = .039). There were nonsignificant trends (P < .10) for plasma levels of IL-1β and HIV RNA to decrease at week 8. Nonsignificant decreases in plasma levels of TNF-α, IL-1β, ID-6, and HIV RNA were also seen in those individuals who remained on stable antiretroviral therapy throughout the 8 weeks of the study.
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U2 - 10.1086/315370
DO - 10.1086/315370
M3 - Article
C2 - 10762582
AN - SCOPUS:0034023315
SN - 0022-1899
VL - 181
SP - 1486
EP - 1490
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -