EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer

Nita Jane Maihle; Jacqueline M. Lafky; Andre T. Baron; Cecelia H. Boardman; Tammy M. Greenwood; Trace A. Christensen; Jill L. Reiter; Elsa M. Cora; Hakjoo Lee; Vera J. Suman; David A. Fishman; Edith A. Perez; Karl C. Podratz

EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer

Nita Jane Maihle, Jacqueline M. Lafky, Andre T. Baron, Cecelia H. Boardman, Tammy M. Greenwood, Trace A. Christensen, Jill L. Reiter, Elsa M. Cora, Hakjoo Lee, Vera J. Suman, David A. Fishman, Edith A. Perez, Karl C. Podratz

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We recently identified several novel transcripts encoding soluble and secreted isoforms of epidermal growth factor receptor (EGFR)/ErbB family members. The EGFR/ErbB family of receptor tyrosine kinases has been implicated in the control of cell growth and differentiation in normal tissues, and the genes encoding these receptors are frequently rearranged and/or overexpressed in a variety of carcinomas. Here, previously published assays useful for the detection of soluble EGFR/ErbB receptor isoforms in human body fluids are briefly reviewed, and results using these assays to analyze sera from breast and ovarian cancer patients are summarized. Together, these results suggest that soluble EGFR/ErbB receptor isoforms are naturally occurring in human circulation, and that they may have clinical utility as both prognostic or diagnostic serum biomarkers in breast and ovarian cancer patients.

Original language	English (US)
Pages (from-to)	57-60
Number of pages	4
Journal	Journal of Clinical Ligand Assay
Volume	25
Issue number	1
State	Published - Mar 1 2002

Keywords

Breast cancer
Epidermal growth factor receptor (EGFR/ErbB)
Ovarian cancer
Receptor tyrosine kinases
Soluble receptors

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer",

abstract = "We recently identified several novel transcripts encoding soluble and secreted isoforms of epidermal growth factor receptor (EGFR)/ErbB family members. The EGFR/ErbB family of receptor tyrosine kinases has been implicated in the control of cell growth and differentiation in normal tissues, and the genes encoding these receptors are frequently rearranged and/or overexpressed in a variety of carcinomas. Here, previously published assays useful for the detection of soluble EGFR/ErbB receptor isoforms in human body fluids are briefly reviewed, and results using these assays to analyze sera from breast and ovarian cancer patients are summarized. Together, these results suggest that soluble EGFR/ErbB receptor isoforms are naturally occurring in human circulation, and that they may have clinical utility as both prognostic or diagnostic serum biomarkers in breast and ovarian cancer patients.",

keywords = "Breast cancer, Epidermal growth factor receptor (EGFR/ErbB), Ovarian cancer, Receptor tyrosine kinases, Soluble receptors",

author = "Maihle, {Nita Jane} and Lafky, {Jacqueline M.} and Baron, {Andre T.} and Boardman, {Cecelia H.} and Greenwood, {Tammy M.} and Christensen, {Trace A.} and Reiter, {Jill L.} and Cora, {Elsa M.} and Hakjoo Lee and Suman, {Vera J.} and Fishman, {David A.} and Perez, {Edith A.} and Podratz, {Karl C.}",

year = "2002",

month = mar,

day = "1",

language = "English (US)",

volume = "25",

pages = "57--60",

journal = "Journal of Clinical Ligand Assay",

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T1 - EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer

AU - Maihle, Nita Jane

AU - Lafky, Jacqueline M.

AU - Baron, Andre T.

AU - Boardman, Cecelia H.

AU - Greenwood, Tammy M.

AU - Christensen, Trace A.

AU - Reiter, Jill L.

AU - Cora, Elsa M.

AU - Lee, Hakjoo

AU - Suman, Vera J.

AU - Fishman, David A.

AU - Perez, Edith A.

AU - Podratz, Karl C.

PY - 2002/3/1

Y1 - 2002/3/1

N2 - We recently identified several novel transcripts encoding soluble and secreted isoforms of epidermal growth factor receptor (EGFR)/ErbB family members. The EGFR/ErbB family of receptor tyrosine kinases has been implicated in the control of cell growth and differentiation in normal tissues, and the genes encoding these receptors are frequently rearranged and/or overexpressed in a variety of carcinomas. Here, previously published assays useful for the detection of soluble EGFR/ErbB receptor isoforms in human body fluids are briefly reviewed, and results using these assays to analyze sera from breast and ovarian cancer patients are summarized. Together, these results suggest that soluble EGFR/ErbB receptor isoforms are naturally occurring in human circulation, and that they may have clinical utility as both prognostic or diagnostic serum biomarkers in breast and ovarian cancer patients.

AB - We recently identified several novel transcripts encoding soluble and secreted isoforms of epidermal growth factor receptor (EGFR)/ErbB family members. The EGFR/ErbB family of receptor tyrosine kinases has been implicated in the control of cell growth and differentiation in normal tissues, and the genes encoding these receptors are frequently rearranged and/or overexpressed in a variety of carcinomas. Here, previously published assays useful for the detection of soluble EGFR/ErbB receptor isoforms in human body fluids are briefly reviewed, and results using these assays to analyze sera from breast and ovarian cancer patients are summarized. Together, these results suggest that soluble EGFR/ErbB receptor isoforms are naturally occurring in human circulation, and that they may have clinical utility as both prognostic or diagnostic serum biomarkers in breast and ovarian cancer patients.

KW - Breast cancer

KW - Epidermal growth factor receptor (EGFR/ErbB)

KW - Ovarian cancer

KW - Receptor tyrosine kinases

KW - Soluble receptors

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M3 - Article

AN - SCOPUS:18544370402

SN - 1081-1672

VL - 25

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JO - Journal of Clinical Ligand Assay

JF - Journal of Clinical Ligand Assay

IS - 1

ER -

EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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