Abstract
In earlier studies we have shown that a protein-synthesis-independent, early, long-term potentiaton (early-LTP) that lasts up to 4–5 hours can be transformed (reinforced) into a protein-synthesis-dependent late-LTP that lasts >8 hours by either an emotional challenge (e.g. swim stress) or mastering a cognitive task (e.g. spatial learning). In the present study we show that LTP-reinforcement by spatial training depends on the specific constraints of the learning paradigm. In a holeboerd paradigm, LTP-reinforcement is related to the formation of a lasting reference memory whereas water-maze training gives more heterog-enous results. Thus, cognitive aspects interfere with emotionally challenging components of the latter paradigm. These data indicate that different spatial-learning tasks are weighted distinctly by the animal. Thus, we show that aspects of specific spatial-learning paradigms such as shifts of attention and emotional content directly influence functional plasticity and memory formation.
Original language | English (US) |
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Pages (from-to) | 253-261 |
Number of pages | 9 |
Journal | Neuron Glia Biology |
Volume | 1 |
Issue number | 3 |
DOIs | |
State | Published - 2004 |
Externally published | Yes |
Keywords
- Stress
- corticosterone
- early-LTP
- holeboard
- late-LTP
- novelty
- water maze
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Cell Biology