Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation

Andreas Lüthi; Herman Van Der Putten; Florence M. Botteri; Isabelle M. Mansuy; Marita Meins; Uwe Frey; Gilles Sansig; Chantal Portet; Markus Schmutz; Markus Schröder; Cordula Nitsch; Jean Paul Laurent; Denis Monard

doi:10.1523/jneurosci.17-12-04688.1997

Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation

Andreas Lüthi, Herman Van Der Putten, Florence M. Botteri, Isabelle M. Mansuy, Marita Meins, Uwe Frey, Gilles Sansig, Chantal Portet, Markus Schmutz, Markus Schröder, Cordula Nitsch, Jean Paul Laurent, Denis Monard

Research output: Contribution to journal › Article › peer-review

157 Scopus citations

Abstract

Protease nexin-1 (PN-1), a member of the serpin superfamily, controls the activity of extracellular serine proteases and is expressed in the brain. Mutant mice overexpressing PN-1 in brain under the control of the Thy-1 promoter (Thy 1/PN-1) or lacking PN-1 (PN-1 -/-) were found to develop epileptic activity in vivo and in vitro. Theta burst-induced long-term potentiation (LTP) and NMDA receptor-mediated synaptic transmission in the CA1 field of hippocampal slices were augmented in Thy 1/PN-1 mice and reduced in PN-1-/mice. Compensatory changes in GABA-mediated inhibition in Thy 1/PN- 1 mice suggest that altered brain PN-1 levels lead to an imbalance between excitatory and inhibitory synaptic transmission.

Original language	English (US)
Pages (from-to)	4688-4699
Number of pages	12
Journal	Journal of Neuroscience
Volume	17
Issue number	12
DOIs	https://doi.org/10.1523/jneurosci.17-12-04688.1997
State	Published - 1997
Externally published	Yes

Keywords

Epileptiform activity
Knock-out and transgenic mice
Long-term potentiation
Protease modulation
Protease nexin-1
Synaptical activity

ASJC Scopus subject areas

General Neuroscience

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10.1523/jneurosci.17-12-04688.1997

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Lüthi, A., Van Der Putten, H., Botteri, F. M., Mansuy, I. M., Meins, M., Frey, U., Sansig, G., Portet, C., Schmutz, M., Schröder, M., Nitsch, C., Laurent, J. P., & Monard, D. (1997). Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation. Journal of Neuroscience, 17(12), 4688-4699. https://doi.org/10.1523/jneurosci.17-12-04688.1997

Lüthi, A, Van Der Putten, H, Botteri, FM, Mansuy, IM, Meins, M, Frey, U, Sansig, G, Portet, C, Schmutz, M, Schröder, M, Nitsch, C, Laurent, JP & Monard, D 1997, 'Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation', Journal of Neuroscience, vol. 17, no. 12, pp. 4688-4699. https://doi.org/10.1523/jneurosci.17-12-04688.1997

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abstract = "Protease nexin-1 (PN-1), a member of the serpin superfamily, controls the activity of extracellular serine proteases and is expressed in the brain. Mutant mice overexpressing PN-1 in brain under the control of the Thy-1 promoter (Thy 1/PN-1) or lacking PN-1 (PN-1 -/-) were found to develop epileptic activity in vivo and in vitro. Theta burst-induced long-term potentiation (LTP) and NMDA receptor-mediated synaptic transmission in the CA1 field of hippocampal slices were augmented in Thy 1/PN-1 mice and reduced in PN-1-/mice. Compensatory changes in GABA-mediated inhibition in Thy 1/PN- 1 mice suggest that altered brain PN-1 levels lead to an imbalance between excitatory and inhibitory synaptic transmission.",

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doi = "10.1523/jneurosci.17-12-04688.1997",

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AU - Van Der Putten, Herman

AU - Botteri, Florence M.

AU - Mansuy, Isabelle M.

AU - Meins, Marita

AU - Frey, Uwe

AU - Sansig, Gilles

AU - Portet, Chantal

AU - Schmutz, Markus

AU - Schröder, Markus

AU - Nitsch, Cordula

AU - Laurent, Jean Paul

AU - Monard, Denis

PY - 1997

Y1 - 1997

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KW - Epileptiform activity

KW - Knock-out and transgenic mice

KW - Long-term potentiation

KW - Protease modulation

KW - Protease nexin-1

KW - Synaptical activity

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Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation

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Keywords

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