Endothelialization of polymer surfaces

D. R. Absolom, L. A. Hawthorn, G. Chang

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The role that substrate surface properties play in influencing the extent of endothelialization of polymer surfaces has been investigated. For a wide range of polymer surfaces, the degree of endothelialization cells is directly related to polymer surface tension: increased endothelialization occurring with increasing substrate surface tension. As a result of adsorption of the proteins in the culture media, the surface properties of the polymers are altered considerably. The protein‐coated polymers were characterized by means of liquid–liquid contact angle measurements under non‐denaturing conditions. A striking correlation is observed between the degree of endothelialization and the measured dextran contact angle. The degree of endothelial cell spreading is not related to polymer surface tension. Cell morphology and extracellular matrix production, however, are influenced by substrate surface properties.

Original languageEnglish (US)
Pages (from-to)271-285
Number of pages15
JournalJournal of Biomedical Materials Research
Issue number4
StatePublished - Apr 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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