Endotoxin and sepsis research: Simplistic approaches have failed

R. D. MacArthur, R. C. Bone

Research output: Contribution to journalEditorialpeer-review


The sepsis syndrome has been revealed to be incredibly complex, involving many mediators that we just now are starting to appreciate. Future clinical trials of new sepsis-related therapeutic products may need to consider other endpoints in addition to mortality. Also, better identification of the subset of patients likely to benefit from these products is necessary, as are rapid diagnostic assays for endotoxin, tumor necrosis factor, and various cytokines.

Original languageEnglish (US)
Pages (from-to)653-654
Number of pages2
JournalComplications in Surgery
Issue number5
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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