Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning

Rezvan Jamaledin; Pooyan Makvandi; Cynthia K.Y. Yiu; Tarun Agarwal; Raffaele Vecchione; Wujin Sun; Tapas Kumar Maiti; Franklin R. Tay; Paolo Antonio Netti

doi:10.1002/adtp.202000171

Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning

Rezvan Jamaledin, Pooyan Makvandi, Cynthia K.Y. Yiu, Tarun Agarwal, Raffaele Vecchione, Wujin Sun, Tapas Kumar Maiti, Franklin R. Tay, Paolo Antonio Netti

Endodontics

Research output: Contribution to journal › Review article › peer-review

70 Scopus citations

Abstract

Transdermal microneedle patches have attracted significant attention in the medical arena over the last decade as alternatives to traditional drug delivery methods. Microneedle patches are capable of delivering their payloads using burst- and sustained-release mechanisms, or in response to internal/external triggers, to optimize their therapeutic potency. Herein, drug release mechanisms and profiles are reviewed, along with the impact of the cargo release on cytotoxicity and delivery efficacy. The potential applications of microneedles in transdermal treatment, from prophylaxis to therapeutics, are also highlighted.

Original language	English (US)
Article number	2000171
Journal	Advanced Therapeutics
Volume	3
Issue number	12
DOIs	https://doi.org/10.1002/adtp.202000171
State	Published - Dec 2020

Keywords

controlled release
drug delivery efficacy
drug release mechanisms
microneedles
responsive microneedles
transdermal patches

ASJC Scopus subject areas

Medicine (miscellaneous)
Pharmacology
Pharmaceutical Science
Genetics(clinical)
Biochemistry, medical
Pharmacology (medical)

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10.1002/adtp.202000171

Cite this

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title = "Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning",

abstract = "Transdermal microneedle patches have attracted significant attention in the medical arena over the last decade as alternatives to traditional drug delivery methods. Microneedle patches are capable of delivering their payloads using burst- and sustained-release mechanisms, or in response to internal/external triggers, to optimize their therapeutic potency. Herein, drug release mechanisms and profiles are reviewed, along with the impact of the cargo release on cytotoxicity and delivery efficacy. The potential applications of microneedles in transdermal treatment, from prophylaxis to therapeutics, are also highlighted.",

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author = "Rezvan Jamaledin and Pooyan Makvandi and Yiu, {Cynthia K.Y.} and Tarun Agarwal and Raffaele Vecchione and Wujin Sun and Maiti, {Tapas Kumar} and Tay, {Franklin R.} and Netti, {Paolo Antonio}",

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doi = "10.1002/adtp.202000171",

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volume = "3",

journal = "Advanced Therapeutics",

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T2 - Recent Advances in Release Profile Tuning

AU - Jamaledin, Rezvan

AU - Makvandi, Pooyan

AU - Yiu, Cynthia K.Y.

AU - Agarwal, Tarun

AU - Vecchione, Raffaele

AU - Sun, Wujin

AU - Maiti, Tapas Kumar

AU - Tay, Franklin R.

AU - Netti, Paolo Antonio

PY - 2020/12

Y1 - 2020/12

N2 - Transdermal microneedle patches have attracted significant attention in the medical arena over the last decade as alternatives to traditional drug delivery methods. Microneedle patches are capable of delivering their payloads using burst- and sustained-release mechanisms, or in response to internal/external triggers, to optimize their therapeutic potency. Herein, drug release mechanisms and profiles are reviewed, along with the impact of the cargo release on cytotoxicity and delivery efficacy. The potential applications of microneedles in transdermal treatment, from prophylaxis to therapeutics, are also highlighted.

AB - Transdermal microneedle patches have attracted significant attention in the medical arena over the last decade as alternatives to traditional drug delivery methods. Microneedle patches are capable of delivering their payloads using burst- and sustained-release mechanisms, or in response to internal/external triggers, to optimize their therapeutic potency. Herein, drug release mechanisms and profiles are reviewed, along with the impact of the cargo release on cytotoxicity and delivery efficacy. The potential applications of microneedles in transdermal treatment, from prophylaxis to therapeutics, are also highlighted.

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KW - drug delivery efficacy

KW - drug release mechanisms

KW - microneedles

KW - responsive microneedles

KW - transdermal patches

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Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning

Abstract

Keywords

ASJC Scopus subject areas

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