TY - JOUR
T1 - Enterococcus faecalis in secondary apical periodontitis
T2 - Mechanisms of bacterial survival and disease persistence
AU - Elashiry, Mohamed M.
AU - Bergeron, Brian E.
AU - Tay, Franklin R.
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/10
Y1 - 2023/10
N2 - Enterococcus faecalis is a commensal bacterium commonly found in the human gastrointestinal tract. However, in individuals with compromised immune systems, the pathogen can lead to severe illness. This opportunistic pathogen is associated with secondary apical diseases and is adept at resisting antibiotics and other forms of treatment because of its numerous virulence factors. Enterococcus faecalis is capable of disrupting the normal functions of immune cells, thereby hindering the body's ability to eradicate the infection. However, intensive research is needed in further understanding the adverse immunomodulatory effects of E. faecalis. Potential strategies specific for eradicating E. faecalis have proven beneficial in the treatment of persistent secondary apical periodontitis.
AB - Enterococcus faecalis is a commensal bacterium commonly found in the human gastrointestinal tract. However, in individuals with compromised immune systems, the pathogen can lead to severe illness. This opportunistic pathogen is associated with secondary apical diseases and is adept at resisting antibiotics and other forms of treatment because of its numerous virulence factors. Enterococcus faecalis is capable of disrupting the normal functions of immune cells, thereby hindering the body's ability to eradicate the infection. However, intensive research is needed in further understanding the adverse immunomodulatory effects of E. faecalis. Potential strategies specific for eradicating E. faecalis have proven beneficial in the treatment of persistent secondary apical periodontitis.
KW - Apical periodontitis
KW - Bacterial persistence
KW - Enterococcus faecalis
KW - Immune cells
KW - Virulence factors
UR - http://www.scopus.com/inward/record.url?scp=85170424987&partnerID=8YFLogxK
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U2 - 10.1016/j.micpath.2023.106337
DO - 10.1016/j.micpath.2023.106337
M3 - Review article
C2 - 37683835
AN - SCOPUS:85170424987
SN - 0882-4010
VL - 183
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
M1 - 106337
ER -