Epigenetic regulation in acute kidney injury: New light in a dark area

Chengyuan Tang; Zheng Dong

doi:10.1038/ki.2015.229

Epigenetic regulation in acute kidney injury: New light in a dark area

Chengyuan Tang, Zheng Dong

Cellular Biology and Anatomy

Research output: Contribution to journal › Comment/debate › peer-review

8 Scopus citations

Abstract

Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury (AKI). Mar et al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable heterogeneity in ischemic and endotoxic AKI. Targeting epigenetic programs may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery.

Original language	English (US)
Pages (from-to)	665-668
Number of pages	4
Journal	Kidney International
Volume	88
Issue number	4
DOIs	https://doi.org/10.1038/ki.2015.229
State	Published - Oct 3 2015

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2015.229

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abstract = "Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury (AKI). Mar et al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable heterogeneity in ischemic and endotoxic AKI. Targeting epigenetic programs may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery.",

author = "Chengyuan Tang and Zheng Dong",

note = "Funding Information: The work of the authors was supported in part by grants from the National Natural Science Foundation of China (81430017, 81370791), the National Basic Research Program of China (973 Program; no. 2012CB517601), and the US National Institutes of Health and Department of Veterans Affairs.",

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N2 - Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury (AKI). Mar et al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable heterogeneity in ischemic and endotoxic AKI. Targeting epigenetic programs may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery.

AB - Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury (AKI). Mar et al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable heterogeneity in ischemic and endotoxic AKI. Targeting epigenetic programs may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery.

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Epigenetic regulation in acute kidney injury: New light in a dark area

Abstract

ASJC Scopus subject areas

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