Epigenetics, stress, and depression

Laura Lockwood; Shaoyong Su; Nagy A. Youssef

doi:10.1016/B978-0-12-823039-8.00004-6

Epigenetics, stress, and depression

Laura Lockwood, Shaoyong Su, Nagy A. Youssef

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Epigenetics involves functional modifications of genes that are affected by environmental factors. The aim of this chapter is to explore if an association exists between epigenetics and depression in humans. Medline/PubMed searches were performed using Medical Subject Heading (MeSH) terms. Based on prespecified terms and inclusion criteria, 16 studies met inclusion criteria by 2 independent reviewers. Epigenetic changes seem to be important in depression. All of the studies reviewed herein found significant epigenetic changes associated with depression. Future research is needed in a larger sample to further characterize these changes.

Original language	English (US)
Title of host publication	Epigenetics of Stress and Stress Disorders
Publisher	Elsevier
Pages	225-238
Number of pages	14
ISBN (Electronic)	9780128230398
ISBN (Print)	9780128230626
DOIs	https://doi.org/10.1016/B978-0-12-823039-8.00004-6
State	Published - Jan 1 2022

Keywords

Epigenomics
Frontal cortex
Genetic sequence
Peripheral blood
Postmortem brain tissue

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-823039-8.00004-6

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abstract = "Epigenetics involves functional modifications of genes that are affected by environmental factors. The aim of this chapter is to explore if an association exists between epigenetics and depression in humans. Medline/PubMed searches were performed using Medical Subject Heading (MeSH) terms. Based on prespecified terms and inclusion criteria, 16 studies met inclusion criteria by 2 independent reviewers. Epigenetic changes seem to be important in depression. All of the studies reviewed herein found significant epigenetic changes associated with depression. Future research is needed in a larger sample to further characterize these changes.",

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AU - Su, Shaoyong

AU - Youssef, Nagy A.

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AB - Epigenetics involves functional modifications of genes that are affected by environmental factors. The aim of this chapter is to explore if an association exists between epigenetics and depression in humans. Medline/PubMed searches were performed using Medical Subject Heading (MeSH) terms. Based on prespecified terms and inclusion criteria, 16 studies met inclusion criteria by 2 independent reviewers. Epigenetic changes seem to be important in depression. All of the studies reviewed herein found significant epigenetic changes associated with depression. Future research is needed in a larger sample to further characterize these changes.

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KW - Frontal cortex

KW - Genetic sequence

KW - Peripheral blood

KW - Postmortem brain tissue

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BT - Epigenetics of Stress and Stress Disorders

PB - Elsevier

ER -

Epigenetics, stress, and depression

Abstract

Keywords

ASJC Scopus subject areas

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