Erythema elevatum diutinum in the setting of connective tissue disease and chronic bacterial infection

Carol M. Woody, Joshua E. Lane, Loretta S. Davis

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21 Scopus citations


Erythema elevatum diutinum (EED) is a rare and chronic cutaneous leukocytoclastic vasculitis. It is predominantly seen on the extensor surfaces of the extremities. Although a specific cause is largely unknown, EED has been noted to occur in association with a wide variety of diseases. A 28-year-old man with systemic lupus erythematosus (SLE) and a 53-year-old woman with an overlap syndrome of rheumatoid arthritis and polymyositis are presented. Both patients developed EED in the setting of chronic recurrent bacterial infections. Patients with a connective tissue disease are at increased risk for such infections secondary to immunosuppression, either from the disease itself or secondary to immunosuppressive therapy. EED has been independently reported to occur in the setting of connective tissue disease as well as in the setting of chronic infection. Our patients had both of these underlying conditions, which are known to predispose patients to immune complex-mediated vasculitides, in this case EED. One patient's EED responded to treatment of the SLE and the other improved, as has been previously reported with dapsone.

Original languageEnglish (US)
Pages (from-to)98-104
Number of pages7
JournalJournal of Clinical Rheumatology
Issue number2
StatePublished - Apr 1 2005


  • Connective tissue disease
  • Erythema elevatum diutinum
  • Recurrent infections

ASJC Scopus subject areas

  • Rheumatology


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