TY - JOUR
T1 - Estimates of pulse wave velocity and measurement of pulse transit time in the human cerebral circulation
AU - Giller, Cole A.
AU - Aaslid, Rune
N1 - Funding Information:
Acknowledgements--The authors are grateful to Janice Dermiston for preparation of this manuscript, and to the Eden Medical Electronic Company for a research grant supporting this work.
PY - 1994
Y1 - 1994
N2 - Knowledge of the velocity with which pressure and flow waves travel within the arterial tree has been fundamental to the understanding of important hemodynamic parameters, such as vessel wall elastance, impedance and reflection coefficients for the systemic circulation. To our knowledge, however, this pulse wave velocity (PWV) has not been previously measured for the human cerebral circulation. In this study, we estimate the PWV from 88 measurements during normocarbia and 95 measurements during hypocarbia in six healthy human volunteers. The measurements consisted of time delays between velocity waveforms obtained simultaneously from the cervical carotid artery and the ipsilateral middle cerebral artery. An estimation of the distance between these sites as 10 centimeters yielded a PWV of 12.8 m/s for both levels of pCO2. Vessel elasticity could then be estimated between 17 and 34 dyne/cm2 · 106. These values of PWV are among the highest of those found in the peripheral circulation, and may have implications for the interpretation of the shape of the cerebral pressure and flow waveforms.
AB - Knowledge of the velocity with which pressure and flow waves travel within the arterial tree has been fundamental to the understanding of important hemodynamic parameters, such as vessel wall elastance, impedance and reflection coefficients for the systemic circulation. To our knowledge, however, this pulse wave velocity (PWV) has not been previously measured for the human cerebral circulation. In this study, we estimate the PWV from 88 measurements during normocarbia and 95 measurements during hypocarbia in six healthy human volunteers. The measurements consisted of time delays between velocity waveforms obtained simultaneously from the cervical carotid artery and the ipsilateral middle cerebral artery. An estimation of the distance between these sites as 10 centimeters yielded a PWV of 12.8 m/s for both levels of pCO2. Vessel elasticity could then be estimated between 17 and 34 dyne/cm2 · 106. These values of PWV are among the highest of those found in the peripheral circulation, and may have implications for the interpretation of the shape of the cerebral pressure and flow waveforms.
KW - Cerebral hemodynamics
KW - Pulse wave velocity
KW - Transcranial Doppler ultrasound
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U2 - 10.1016/0301-5629(94)90074-4
DO - 10.1016/0301-5629(94)90074-4
M3 - Article
C2 - 7912867
AN - SCOPUS:0028215551
SN - 0301-5629
VL - 20
SP - 101
EP - 105
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 2
ER -
