TY - JOUR
T1 - Euphorbiaceae latex induced green synthesis of non-cytotoxic metallic nanoparticle solutions
T2 - A rational approach to antimicrobial applications
AU - Valodkar, Mayur
AU - Nagar, Padamanabhi S.
AU - Jadeja, Ravirajsinh N.
AU - Thounaojam, Menaka C.
AU - Devkar, Ranjitsinh V.
AU - Thakore, Sonal
N1 - Funding Information:
The authors are grateful to the University Grants Commission , New Delhi for financial assistance. Special thanks to Dr. Jayshree Pornerkar and Mrs. Mukta Mohan, Department of Biochemistry, for antibacterial studies and Dr. Bhavna Trivedi and Mr. Shardul Bhatt Department of Chemistry, for cyclic voltammograms studies.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2011/7/5
Y1 - 2011/7/5
N2 - The stem latex of a medicinally important plant, Euphorbia nivulia was successfully used to induce room temperature/microwave synthesis of silver and copper nanoparticles even at high concentrations. The major component of the latex, Euphol, is assumed to be the reducing moiety; while stabilization is assisted by certain peptides and terpenoids present within the latex as supported by the FT-IR analysis. The fast and simple process has high reproducibility and leads to formation of nanoparticles with 5-10. nm diameter. The one step synthesis can be extended for other metals. The nanoparticle solutions being completely free of toxic chemicals can be directly used for antimicrobial tests. The as synthesized solutions of both metals exhibited excellent bactericidal action against both gram negative and gram positive bacteria well below the in vitro cytotoxic concentration. The non-cytotoxic metal-latex aqueous solution offers a rational approach towards antimicrobial application and for integration to biomedical devices.
AB - The stem latex of a medicinally important plant, Euphorbia nivulia was successfully used to induce room temperature/microwave synthesis of silver and copper nanoparticles even at high concentrations. The major component of the latex, Euphol, is assumed to be the reducing moiety; while stabilization is assisted by certain peptides and terpenoids present within the latex as supported by the FT-IR analysis. The fast and simple process has high reproducibility and leads to formation of nanoparticles with 5-10. nm diameter. The one step synthesis can be extended for other metals. The nanoparticle solutions being completely free of toxic chemicals can be directly used for antimicrobial tests. The as synthesized solutions of both metals exhibited excellent bactericidal action against both gram negative and gram positive bacteria well below the in vitro cytotoxic concentration. The non-cytotoxic metal-latex aqueous solution offers a rational approach towards antimicrobial application and for integration to biomedical devices.
KW - Bactericidal
KW - Cytotoxicity
KW - Latex
KW - Nanomaterials
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U2 - 10.1016/j.colsurfa.2011.04.015
DO - 10.1016/j.colsurfa.2011.04.015
M3 - Article
AN - SCOPUS:79959741204
SN - 0927-7757
VL - 384
SP - 337
EP - 344
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
IS - 1-3
ER -
