TY - JOUR
T1 - Evaluation of polyethylene glycol/polylactic acid films in the prevention of adhesions in the rabbit adhesion formation and reformation sidewall models
AU - Rodgers, Kathleen
AU - Cohn, Daniel
AU - Hotovely, Anna
AU - Pines, Eli
AU - Diamond, Michael Peter
AU - Dizerega, Gere
N1 - Funding Information:
Supported by Life Medical Sciences, Inc., Edison, New Jersey.
PY - 1998
Y1 - 1998
N2 - Objective: To assess the efficacy of bioresorbable films consisting of various polyethylene glycol 6000 and polylactic acid block copolymers on the formation and reformation of adhesions in rabbit models of adhesion development between the sidewall to the adjacent cecum and bowel. The composition of the different polymers was expressed by the number of monomeric units in the block, namely, ethylene oxide (EO) and lactic acid (LA), respectively. Design: Studies of the efficacy of EO/LA films were conducted in rabbit sidewall adhesion formation studies in the presence and absence of blood and in rabbit adhesion reformation studies. REPEL (Life Medical Sciences, Edison, NJ), a film of EO/LA ratio 3.0 manufactured under commercial conditions, was also tested in these animal models. Setting: University-based laboratory. Animals: New Zealand white rabbits. Intervention(s): Placement of films of various EO/LA ratios at the site of injury to the parietal peritoneum. Main Outcome Measure(s): Adhesion formation and reformation. Result(s): Films of various EO/LA ratios, Seprafilm (Genzyme, Cambridge, MA) and Interceed (Johnson and Johnson Medical, Arlington, TX) placed over an area of excised sidewall at the time of initial injury were highly efficacious in the prevention of adhesion formation. A film of EO/LA ratio 3.7, in contrast with Interceed, was also shown to maintain maximal efficacy in the reduction of adhesion formation in the presence of blood. Further, a film of EO/LA ratio 3.0 produced under commercial conditions, REPEL, was highly efficacious in reducing adhesion development in the rabbit models of adhesion and reformation. Conclusion(s): These studies suggest that bioresorbable EO/LA films reduced adhesion development in rabbit models of adhesion formation and reformation.
AB - Objective: To assess the efficacy of bioresorbable films consisting of various polyethylene glycol 6000 and polylactic acid block copolymers on the formation and reformation of adhesions in rabbit models of adhesion development between the sidewall to the adjacent cecum and bowel. The composition of the different polymers was expressed by the number of monomeric units in the block, namely, ethylene oxide (EO) and lactic acid (LA), respectively. Design: Studies of the efficacy of EO/LA films were conducted in rabbit sidewall adhesion formation studies in the presence and absence of blood and in rabbit adhesion reformation studies. REPEL (Life Medical Sciences, Edison, NJ), a film of EO/LA ratio 3.0 manufactured under commercial conditions, was also tested in these animal models. Setting: University-based laboratory. Animals: New Zealand white rabbits. Intervention(s): Placement of films of various EO/LA ratios at the site of injury to the parietal peritoneum. Main Outcome Measure(s): Adhesion formation and reformation. Result(s): Films of various EO/LA ratios, Seprafilm (Genzyme, Cambridge, MA) and Interceed (Johnson and Johnson Medical, Arlington, TX) placed over an area of excised sidewall at the time of initial injury were highly efficacious in the prevention of adhesion formation. A film of EO/LA ratio 3.7, in contrast with Interceed, was also shown to maintain maximal efficacy in the reduction of adhesion formation in the presence of blood. Further, a film of EO/LA ratio 3.0 produced under commercial conditions, REPEL, was highly efficacious in reducing adhesion development in the rabbit models of adhesion and reformation. Conclusion(s): These studies suggest that bioresorbable EO/LA films reduced adhesion development in rabbit models of adhesion formation and reformation.
KW - Adhesions
KW - Barrier
KW - Bioresorbable
KW - Polyethylene glycol
KW - Polylactic acid
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U2 - 10.1016/s0015-0282(97)00574-8
DO - 10.1016/s0015-0282(97)00574-8
M3 - Article
C2 - 9531866
AN - SCOPUS:0031953390
SN - 0015-0282
VL - 69
SP - 403
EP - 408
JO - Fertility and sterility
JF - Fertility and sterility
IS - 3 SUPPL. 2
ER -