Exercise dose response in muscle

B. D. Duscha, B. H. Annex, J. L. Johnson, K. Huffman, J. Houmard, W. E. Kraus

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Exercise increases peak VO 2 partially through muscle adaptations. However, understanding muscle adaptations related to exercise dose is incomplete. This study investigated exercise training dose on capillaries per fiber and capillaries per area; and citrate synthase from vastus lateralis and related both to changes in peak VO 2. This randomized trial compared 3 exercise doses: low amount-moderate intensity (n=40) , low amount-high intensity (n=47), high amount-high intensity (n=41), and a control group (n=35). Both measures of capillary supply increased in all exercise groups (p<0.05). Low amount-high intensity and high amount-high intensity improved citrate synthase (p<0.05) and the low amount-moderate intensity citrate synthase approached significance (p=0.059). Muscle improvements were only related to improvements in peak VO 2 in high amount-high intensity (citrate synthase, r=-0.304; capillaries:fiber, r=-0.318; p<0.05 and capillaries/mm 2 r=-0.310, p<0.05). These data suggest muscle adaptations occur following both low and high exercise doses, but are only related to improved peak VO 2 following high amount-high intensity training.

Original languageEnglish (US)
Pages (from-to)218-223
Number of pages6
JournalInternational Journal of Sports Medicine
Issue number3
StatePublished - 2012
Externally publishedYes


  • capillary density
  • citrate synthase
  • exercise training
  • muscle adaptations

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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