Exercise testing in patients with cystic fibrosis—importance of ventilatory parameters

Matthew A. Tucker, Nichole Lee, Paula Rodriguez-Miguelez, Jacob Looney, Reva H. Crandall, Caralee Forseen, Kathleen T. McKie, Ryan A. Harris

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Ventilatory parameters obtained during exercise predict survival in several chronic diseases; however, long-term changes in exercise ventilatory parameters in patients with cystic fibrosis (CF) have yet to be examined and potential differences between sexes in CF are unknown. Purpose: We sought to examine the change in exercise ventilatory parameters over time in patients with CF and determine if the change is different between sexes. Methods: Exercise capacity (VO 2 peak) and exercise ventilatory parameters (V E /VO 2 peak, V E /VCO 2 peak, and V E /VCO 2 slope) were determined from a maximal cardio-pulmonary test on a cycle ergometer on two visits separated by 39 ± 16 months in 20 patients with CF (10 female, 10 male). Results: No differences between sexes were observed at visit 1 (all p > 0.05). Overall, exercise ventilatory parameters significantly (p < 0.05) deteriorated between visits, with no change (p > 0.05) in VO 2 peak. Moreover, compared to males, female patients exhibited greater deteriorations in V E /VO 2 peak (p = 0.001), V E /VCO 2 peak (p = 0.002), and V E /VCO 2 slope (p = 0.016) between visits. Conclusions: These data in patients with CF indicate that exercise ventilatory parameters decline over time despite no change in VO 2 peak, and female patients exhibit a more rapid deterioration compared to males.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalEuropean Journal of Applied Physiology
Issue number1
StatePublished - Jan 30 2019


  • Exercise capacity
  • Pulmonary function
  • Ventilatory efficiency

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)


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