TY - JOUR
T1 - Exploration of the role of radiotherapy in the management of early glottic cancer with complete carotid artery occlusion
AU - Mourad, Waleed Fouad
AU - Hu, Kenneth S.
AU - Shourbaji, Rania A.
AU - Dolan, James
AU - Blakaj, Dukagjin M.
AU - Shasha, Daniel
AU - Harrison, Louis B.
PY - 2013/8
Y1 - 2013/8
N2 - Background: The aim of this study was to compare intensity-modulated radiation therapy (IMRT) vs. 2D and 3D radiotherapy (RT) in the treatment of T1 glottic squamous cell carcinoma in an effort to highlight the advantages of IMRT in this particular clinical situation. Case Report: We present the case of an 82-year-old female patient with T1 left true vocal cord squamous cell carcinoma and complete occlusion of the left carotid artery resulting in multiple strokes. The patient underwent definitive RT with 63 Gy (28 × 2.25 Gy). 3 plans were generated: 2D RT, 3D RT, and IMRT. The right carotid artery (Rt.CA) mean dose was 865, 2,065, and 4,268 cGy for IMRT, 3D RT, and 2D RT, respectively. The inferior pharyngeal constrictor (IPC) mean dose was 5,341, 6,456, and 6,451 cGy for IMRT, 3D RT, and 2D RT, respectively. IMRT provided the best homogeneity but at a higher cost and with prolonged treatment time. Conclusion: IMRT provided the finest planning target volume coverage with minimal Rt.CA and IPC doses. IMRT is recommended in certain clinical scenarios which are not manageable with other techniques.
AB - Background: The aim of this study was to compare intensity-modulated radiation therapy (IMRT) vs. 2D and 3D radiotherapy (RT) in the treatment of T1 glottic squamous cell carcinoma in an effort to highlight the advantages of IMRT in this particular clinical situation. Case Report: We present the case of an 82-year-old female patient with T1 left true vocal cord squamous cell carcinoma and complete occlusion of the left carotid artery resulting in multiple strokes. The patient underwent definitive RT with 63 Gy (28 × 2.25 Gy). 3 plans were generated: 2D RT, 3D RT, and IMRT. The right carotid artery (Rt.CA) mean dose was 865, 2,065, and 4,268 cGy for IMRT, 3D RT, and 2D RT, respectively. The inferior pharyngeal constrictor (IPC) mean dose was 5,341, 6,456, and 6,451 cGy for IMRT, 3D RT, and 2D RT, respectively. IMRT provided the best homogeneity but at a higher cost and with prolonged treatment time. Conclusion: IMRT provided the finest planning target volume coverage with minimal Rt.CA and IPC doses. IMRT is recommended in certain clinical scenarios which are not manageable with other techniques.
KW - 2D RT
KW - 3D RT
KW - Carotid-sparing
KW - Early cancer larynx
KW - IMRT
KW - T1 glottic squamous cell carcinoma
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UR - http://www.scopus.com/inward/citedby.url?scp=84882307304&partnerID=8YFLogxK
U2 - 10.1159/000353750
DO - 10.1159/000353750
M3 - Article
C2 - 23921763
AN - SCOPUS:84882307304
SN - 0378-584X
VL - 36
SP - 433
EP - 435
JO - Onkologie(Czech Republic)
JF - Onkologie(Czech Republic)
IS - 7-8
ER -
