Expression of H-2 class I genes in murine extra-embryonic tissues

K. L. Philpott, S. Rastan, S. Brown, A. L. Mellor

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Murine major histocompatibility complex class I genes are transcribed at high levels in placental tissues, lower levels in yolk-sac tissues and at barely detectable levels in the embryo at Day 13.5 of gestation. Genes are expressed at equivalent levels whether inherited maternally or paternally, and the gentic background has no effect on class I gene transcription. These results show that potential alloantigens are expressed in extra-embryonic tissues intimately associated with maternal tissues and blood supply and yet fail to induce immunological rejection.

Original languageEnglish (US)
Pages (from-to)479-485
Number of pages7
Issue number3
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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