Extracellular Vesicles That Herald the Scarcity of Oxygen

Sekyung Oh; Sang Ho Kwon

doi:10.1159/000524423

Extracellular Vesicles That Herald the Scarcity of Oxygen

Sekyung Oh, Sang Ho Kwon

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

The natural, membrane-bound nanoscale particles, called extracellular vesicles (EVs) have emerged as an effective, versatile vehicle to transport desired drugs specifically to injury sites. Heralding the presence of the scarcity of oxygen, EVs produced from the cells upregulating the expression of the critical transcriptional regulator of hypoxia, HIF-1, can induce a response in ischemia-reperfusion-damaged cells to ameliorate renal tubular injury and inflammation.

Original language	English (US)
Pages (from-to)	202-205
Number of pages	4
Journal	Kidney Diseases
Volume	8
Issue number	3
DOIs	https://doi.org/10.1159/000524423
State	Published - May 22 2022
Externally published	Yes

Keywords

Exosomes
Extracellular vesicles
Hypoxia
Ischemia
Kidney injury

ASJC Scopus subject areas

Nephrology

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10.1159/000524423

Cite this

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abstract = "The natural, membrane-bound nanoscale particles, called extracellular vesicles (EVs) have emerged as an effective, versatile vehicle to transport desired drugs specifically to injury sites. Heralding the presence of the scarcity of oxygen, EVs produced from the cells upregulating the expression of the critical transcriptional regulator of hypoxia, HIF-1, can induce a response in ischemia-reperfusion-damaged cells to ameliorate renal tubular injury and inflammation.",

keywords = "Exosomes, Extracellular vesicles, Hypoxia, Ischemia, Kidney injury",

author = "Sekyung Oh and Kwon, {Sang Ho}",

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AU - Kwon, Sang Ho

PY - 2022/5/22

Y1 - 2022/5/22

N2 - The natural, membrane-bound nanoscale particles, called extracellular vesicles (EVs) have emerged as an effective, versatile vehicle to transport desired drugs specifically to injury sites. Heralding the presence of the scarcity of oxygen, EVs produced from the cells upregulating the expression of the critical transcriptional regulator of hypoxia, HIF-1, can induce a response in ischemia-reperfusion-damaged cells to ameliorate renal tubular injury and inflammation.

AB - The natural, membrane-bound nanoscale particles, called extracellular vesicles (EVs) have emerged as an effective, versatile vehicle to transport desired drugs specifically to injury sites. Heralding the presence of the scarcity of oxygen, EVs produced from the cells upregulating the expression of the critical transcriptional regulator of hypoxia, HIF-1, can induce a response in ischemia-reperfusion-damaged cells to ameliorate renal tubular injury and inflammation.

KW - Exosomes

KW - Extracellular vesicles

KW - Hypoxia

KW - Ischemia

KW - Kidney injury

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DO - 10.1159/000524423

M3 - Review article

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ER -

Extracellular Vesicles That Herald the Scarcity of Oxygen

Abstract

Keywords

ASJC Scopus subject areas

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