Extrapyramidal side-effects of antipsychotics in a randomised trial

Del D. Miller, Stanley N. Caroff, Sonia M. Davis, Robert A. Rosenheck, Joseph Patrick McEvoy, Bruce L. Saltz, Silvana Riggio, Miranda H. Chakos, Marvin S. Swartz, Richard S.E. Keefe, T. Scott Stroup, Jeffrey A. Lieberman

Research output: Contribution to journalArticlepeer-review

207 Scopus citations


Background There are claims that second-generation antipsychotics produce fewer extrapyramidal side-effects (EPS) compared with first-generation drugs. Alms To compare the incidence of treatment-emergent EPS between second-generation antipsychotics and perphenazine in people with schizophrenia. Method incidence analyses integrated data from standardised rating scales and documented use of concomitant medication or treatment discontinuation for EPS events. Mixed model analyses of change in rating scales from baseline were also conducted. Results There were no significant differences in incidence or change in rating scales for parkinsonism, dystonia, akathisia or tardive dyskinesia when comparing secondgeneration antipsychotics with perphenazine or comparing between second-generation antipsychotics. secondary analyses revealed greater rates of concomitant antiparkinsonism medication among individuals on risperidone and lower rates among individuals on quetiapine, and lower rates of discontinuation because of parkinsonism among people on quetiapine and ziprasidone. There was a trend for a greater likelihood of concomitant medication for akathisia among individuals on risperidone and perphenazine. Conclusions The incidence of treatment-emergent EPS and change in EPS ratings indicated that there are no significant differences between second-generation antipsychotics and perphenazine or between second-generation antipsychotics in people with schizophrenia.

Original languageEnglish (US)
Pages (from-to)279-288
Number of pages10
JournalBritish Journal of Psychiatry
Issue number4
StatePublished - Oct 2008
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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