FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells

Chor Fung Ng; Patrick Kwok Shing Ng; Vivian Wai Yan Lui; Jialiang Li; Judy Yuet Wa Chan; Kwok Pui Fung; Yuen Keng Ng; Paul Bo San Lai; Stephen Kwok Wing Tsui

doi:10.1016/j.canlet.2011.02.001

FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells

Chor Fung Ng, Patrick Kwok Shing Ng, Vivian Wai Yan Lui, Jialiang Li, Judy Yuet Wa Chan, Kwok Pui Fung, Yuen Keng Ng, Paul Bo San Lai, Stephen Kwok Wing Tsui

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

FHL2 displays tumor promoting or tumor suppressing activities depending on the types of tumor cells. In this study, we demonstrated that FHL2 overexpression inhibits the proliferation of human HCC cells Hep3B through cell cycle regulation by decreasing cyclin D1 expression while increasing the expressions of p21 and p27. FHL2 overexpression also inhibits migration and invasion of Hep3B cells through the regulation of epithelial-mesenchymal transition. Surprisingly, we also demonstrated an antiapoptotic function for FHL2 overexpression with increased resistance to doxorubicin-induced apoptosis, which indicates the separation of anti-proliferative and anti-apoptotic role of FHL2. Taken together, our results indicate FHL2 could exert anti-apoptotic effect independent of tumor growth suppression.

Original language	English (US)
Pages (from-to)	97-106
Number of pages	10
Journal	Cancer Letters
Volume	304
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2011.02.001
State	Published - May 28 2011
Externally published	Yes

Keywords

Apoptosis
FHL2
Liver cancer
Proliferation

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2011.02.001

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title = "FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells",

abstract = "FHL2 displays tumor promoting or tumor suppressing activities depending on the types of tumor cells. In this study, we demonstrated that FHL2 overexpression inhibits the proliferation of human HCC cells Hep3B through cell cycle regulation by decreasing cyclin D1 expression while increasing the expressions of p21 and p27. FHL2 overexpression also inhibits migration and invasion of Hep3B cells through the regulation of epithelial-mesenchymal transition. Surprisingly, we also demonstrated an antiapoptotic function for FHL2 overexpression with increased resistance to doxorubicin-induced apoptosis, which indicates the separation of anti-proliferative and anti-apoptotic role of FHL2. Taken together, our results indicate FHL2 could exert anti-apoptotic effect independent of tumor growth suppression.",

keywords = "Apoptosis, FHL2, Liver cancer, Proliferation",

author = "Ng, {Chor Fung} and Ng, {Patrick Kwok Shing} and Lui, {Vivian Wai Yan} and Jialiang Li and Chan, {Judy Yuet Wa} and Fung, {Kwok Pui} and Ng, {Yuen Keng} and Lai, {Paul Bo San} and Tsui, {Stephen Kwok Wing}",

year = "2011",

month = may,

day = "28",

doi = "10.1016/j.canlet.2011.02.001",

language = "English (US)",

volume = "304",

pages = "97--106",

journal = "Cancer Letters",

issn = "0304-3835",

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T1 - FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells

AU - Ng, Chor Fung

AU - Ng, Patrick Kwok Shing

AU - Lui, Vivian Wai Yan

AU - Li, Jialiang

AU - Chan, Judy Yuet Wa

AU - Fung, Kwok Pui

AU - Ng, Yuen Keng

AU - Lai, Paul Bo San

AU - Tsui, Stephen Kwok Wing

PY - 2011/5/28

Y1 - 2011/5/28

N2 - FHL2 displays tumor promoting or tumor suppressing activities depending on the types of tumor cells. In this study, we demonstrated that FHL2 overexpression inhibits the proliferation of human HCC cells Hep3B through cell cycle regulation by decreasing cyclin D1 expression while increasing the expressions of p21 and p27. FHL2 overexpression also inhibits migration and invasion of Hep3B cells through the regulation of epithelial-mesenchymal transition. Surprisingly, we also demonstrated an antiapoptotic function for FHL2 overexpression with increased resistance to doxorubicin-induced apoptosis, which indicates the separation of anti-proliferative and anti-apoptotic role of FHL2. Taken together, our results indicate FHL2 could exert anti-apoptotic effect independent of tumor growth suppression.

AB - FHL2 displays tumor promoting or tumor suppressing activities depending on the types of tumor cells. In this study, we demonstrated that FHL2 overexpression inhibits the proliferation of human HCC cells Hep3B through cell cycle regulation by decreasing cyclin D1 expression while increasing the expressions of p21 and p27. FHL2 overexpression also inhibits migration and invasion of Hep3B cells through the regulation of epithelial-mesenchymal transition. Surprisingly, we also demonstrated an antiapoptotic function for FHL2 overexpression with increased resistance to doxorubicin-induced apoptosis, which indicates the separation of anti-proliferative and anti-apoptotic role of FHL2. Taken together, our results indicate FHL2 could exert anti-apoptotic effect independent of tumor growth suppression.

KW - Apoptosis

KW - FHL2

KW - Liver cancer

KW - Proliferation

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JO - Cancer Letters

JF - Cancer Letters

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ER -

FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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