TY - JOUR
T1 - Fibroblasts at the curtain call
T2 - from ensemble to principal dancers in immunometabolism and inflammaging
AU - Serrano-Lopez, Rogelio
AU - Morandini, Ana Carolina
N1 - Publisher Copyright:
© 2023, Faculdade de Odontologia de Bauru da Universidade de Sao Paulo. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Inflammation is a necessary step in response to injuries, being vital in restoring homeostasis and facilitating tissue healing. Among the cells that play a crucial role in inflammatory responses, stromal cells, including fibroblasts, have an undeniable significance in fine-tuning the magnitude of mediators that directly affect hyper-inflammatory responses and tissue destruction. Fibroblasts, the dominant cells in the gingival connective tissue, are a very heterogeneous population of cells, and more recently they have been receiving well deserved attention as central players and often the ‘principal dancers’ of many pathological processes ranging from inflammation and fibrosis to altered immunity and cancer. The goal of the current investigation is to dive into the exact role of the stromal fibroblast and the responsible mechanistic factors involved in both regulation and dysregulation of the inflammatory responses. This article reviews the most recent literature on how fibroblasts, in their different activation states or subtypes, play a crucial role in contributing to inflammatory outcomes. We will focus on recent findings on inflammatory diseases. We will also provide connections regarding the stromal-immune relationship, which supports the idea of fibroblast coming out from the ‘ensemble’ of cell types to the protagonist role in immunometabolism and inflammaging. Additionally, we discuss the current advances in variation of fibroblast nomenclature and division into clusters with their own suggested function and particularities in gene expression. Here, we provide a perspective for the periodontal implications, discussing the fibroblast role in the infection-driven and inflammatory mediated diseases such as periodontitis.
AB - Inflammation is a necessary step in response to injuries, being vital in restoring homeostasis and facilitating tissue healing. Among the cells that play a crucial role in inflammatory responses, stromal cells, including fibroblasts, have an undeniable significance in fine-tuning the magnitude of mediators that directly affect hyper-inflammatory responses and tissue destruction. Fibroblasts, the dominant cells in the gingival connective tissue, are a very heterogeneous population of cells, and more recently they have been receiving well deserved attention as central players and often the ‘principal dancers’ of many pathological processes ranging from inflammation and fibrosis to altered immunity and cancer. The goal of the current investigation is to dive into the exact role of the stromal fibroblast and the responsible mechanistic factors involved in both regulation and dysregulation of the inflammatory responses. This article reviews the most recent literature on how fibroblasts, in their different activation states or subtypes, play a crucial role in contributing to inflammatory outcomes. We will focus on recent findings on inflammatory diseases. We will also provide connections regarding the stromal-immune relationship, which supports the idea of fibroblast coming out from the ‘ensemble’ of cell types to the protagonist role in immunometabolism and inflammaging. Additionally, we discuss the current advances in variation of fibroblast nomenclature and division into clusters with their own suggested function and particularities in gene expression. Here, we provide a perspective for the periodontal implications, discussing the fibroblast role in the infection-driven and inflammatory mediated diseases such as periodontitis.
KW - Aging
KW - Fibroblasts
KW - Inflammation
KW - Metabolism
KW - Stromal cells
UR - http://www.scopus.com/inward/record.url?scp=85163718104&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85163718104&partnerID=8YFLogxK
U2 - 10.1590/1678-7757-2023-0050
DO - 10.1590/1678-7757-2023-0050
M3 - Review article
C2 - 37377310
AN - SCOPUS:85163718104
SN - 1678-7757
VL - 31
JO - Journal of Applied Oral Science
JF - Journal of Applied Oral Science
M1 - e20230050
ER -