Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain

Nagendran Muthusamy; Andrew Brumm; Xuying Zhang; S. Thomas Carmichael; H. Troy Ghashghaei

doi:10.1038/s41598-018-19913-x

Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain

Nagendran Muthusamy, Andrew Brumm, Xuying Zhang, S. Thomas Carmichael, H. Troy Ghashghaei

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. Non stem-And progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.

Original language	English (US)
Article number	1766
Journal	Scientific reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-19913-x
State	Published - Dec 1 2018
Externally published	Yes

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abstract = "The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. Non stem-And progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.",

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AU - Brumm, Andrew

AU - Zhang, Xuying

AU - Carmichael, S. Thomas

AU - Ghashghaei, H. Troy

N1 - Publisher Copyright: © The Author(s) 2018.

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Y1 - 2018/12/1

N2 - The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. Non stem-And progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.

AB - The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. Non stem-And progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.

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Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain

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