GAIT-GM integrative cross-omics analyses reveal cholinergic defects in a C. elegans model of Parkinson’s disease

Keyphrases

• Caenorhabditis Elegans 100%
• Parkinson's Disease Model 100%
• Cross-omics Analysis 100%
• Parkinson's Disease 80%
• Disease Mechanisms 60%
• Cholinergic Neurons 60%
• Galaxies 60%
• Integrative Analysis 40%
• Neurodegeneration 20%
• Dopaminergic Neurons 20%
• High-throughput 20%
• Challenging Tasks 20%
• Molecular Targets 20%
• Neurodegenerative Diseases 20%
• Scientific Community 20%
• Gene Expression Level 20%
• Multiple Cell Types 20%
• Complex Disease 20%
• Bioinformatics Analysis 20%
• Metabolomics 20%
• Cell Loss 20%
• Transcriptomics 20%
• Metabolite Concentrations 20%
• Molecular Profiling 20%
• Testable Hypothesis 20%
• Tractable Models 20%
• Omics Data 20%
• Follow-up Experiment 20%
• Multi-omics Analysis 20%
• Profiling Technology 20%
• Branched-chain Amino Acid Metabolism 20%
• Bioinformatics Training 20%
• Cholinergic Neurodegeneration 20%
• Multi-omics Integration 20%

Biochemistry, Genetics and Molecular Biology

• Caenorhabditis Elegans 100%
• Cholinergic 100%
• Metabolite 40%
• Cholinergic Neuron 40%
• Dopaminergic 20%
• Gene Expression 20%
• Transcriptomics 20%
• Metabolomics 20%
• Cell Loss 20%
• Amino Acid Metabolism 20%

Neuroscience

• Parkinson's Disease 100%
• Cholinergic 100%
• Neurodegeneration 28%
• Metabolic Pathway 14%
• Gene Expression 14%
• Neurodegenerative Disorder 14%
• Dopaminergic 14%
• Transcriptomics 14%
• Cell Loss 14%
• Branched-Chain Amino Acid 14%