Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia

Jeff T Wilkins, Edward V Agabin, Jason Varghese, Asif Talukder

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


The prevalence of gallstones is 10% to 15% in adults. Individuals with acute cholecystitis present with right upper quadrant pain, fever, and leukocytosis. Management includes supportive care and cholecystectomy. The prevalence of choledocholithiasis is 10% to 20%, and serious complications include cholangitis and gallstone pancreatitis. The goal of management in individuals with choledocholithiasis consists of clearing common bile duct stones. Acute ascending cholangitis is a life-threatening condition involving acute inflammation and infection of the common bile duct. Treatment includes intravenous fluids, analgesia, intravenous antibiotics, and biliary drainage and decompression. Biliary dyskinesia includes motility disorders resulting in biliary colic in the absence of gallstones.

Original languageEnglish (US)
Pages (from-to)575-597
Number of pages23
JournalPrimary Care - Clinics in Office Practice
Issue number4
StatePublished - Dec 1 2017


  • Acute cholecystitis
  • Ascending cholangitis
  • Biliary dyskinesia
  • Choledocholithiasis
  • Cholelithiasis
  • Functional gallbladder disorder
  • Sphincter of Oddi disorders

ASJC Scopus subject areas

  • Pharmacology (medical)


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