Gastrointestinal stromal tumor of the posterior mediastinum

Jeffrey R. Lee, Mark P. Anstadt, Shamsuddin Khwaja, Linda K. Green

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Gastrointestinal stromal tumor (GIST) is a rare, but potentially aggressive tumor. We present an asymptomatic 64-year-old man with an incidental 9-cm GIST that arose in the posterior mediastinum. Wide surgical excision was performed with rotation of an intercostal muscle flap to buttress a surgically created esophageal wall defect. The patient is now free of disease 26 months postoperative. This tumor is defined by the carcinogenic over-expression of KIT-protein, a tyrosine kinase receptor. Accurate diagnosis of gastrointestinal stromal tumor is imperative, as specific medical therapy is now available for potential control of recurrent or metastatic disease.

Original languageEnglish (US)
Pages (from-to)1014-1016
Number of pages3
JournalEuropean Journal of Cardio-thoracic Surgery
Issue number6
StatePublished - Dec 1 2002


  • Esophagus
  • Gastrointestinal autonomic nerve tumor (GANT)
  • Gastrointestinal stromal tumor (GIST)
  • KIT
  • Mediastinum

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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