TY - JOUR
T1 - Genomics for Emerging Pathogen Identification and Monitoring
T2 - Prospects and Obstacles
AU - Vashisht, Vishakha
AU - Vashisht, Ashutosh
AU - Mondal, Ashis K.
AU - Farmaha, Jaspreet
AU - Alptekin, Ahmet
AU - Singh, Harmanpreet
AU - Ahluwalia, Pankaj
AU - Srinivas, Anaka
AU - Kolhe, Ravindra
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/12
Y1 - 2023/12
N2 - Emerging infectious diseases (EIDs) pose an increasingly significant global burden, driven by urbanization, population explosion, global travel, changes in human behavior, and inadequate public health systems. The recent SARS-CoV-2 pandemic highlights the urgent need for innovative and robust technologies to effectively monitor newly emerging pathogens. Rapid identification, epidemiological surveillance, and transmission mitigation are crucial challenges for ensuring public health safety. Genomics has emerged as a pivotal tool in public health during pandemics, enabling the diagnosis, management, and prediction of infections, as well as the analysis and identification of cross-species interactions and the categorization of infectious agents. Recent advancements in high-throughput DNA sequencing tools have facilitated rapid and precise identification and characterization of emerging pathogens. This review article provides insights into the latest advances in various genomic techniques for pathogen detection and tracking and their applications in global outbreak surveillance. We assess methods that leverage pathogen sequences and explore the role of genomic analysis in understanding the epidemiology of newly emerged infectious diseases. Additionally, we address technical challenges and limitations, ethical and legal considerations, and highlight opportunities for integrating genomics with other surveillance approaches. By delving into the prospects and obstacles of genomics, we can gain valuable insights into its role in mitigating the threats posed by emerging pathogens and improving global preparedness in the face of future outbreaks.
AB - Emerging infectious diseases (EIDs) pose an increasingly significant global burden, driven by urbanization, population explosion, global travel, changes in human behavior, and inadequate public health systems. The recent SARS-CoV-2 pandemic highlights the urgent need for innovative and robust technologies to effectively monitor newly emerging pathogens. Rapid identification, epidemiological surveillance, and transmission mitigation are crucial challenges for ensuring public health safety. Genomics has emerged as a pivotal tool in public health during pandemics, enabling the diagnosis, management, and prediction of infections, as well as the analysis and identification of cross-species interactions and the categorization of infectious agents. Recent advancements in high-throughput DNA sequencing tools have facilitated rapid and precise identification and characterization of emerging pathogens. This review article provides insights into the latest advances in various genomic techniques for pathogen detection and tracking and their applications in global outbreak surveillance. We assess methods that leverage pathogen sequences and explore the role of genomic analysis in understanding the epidemiology of newly emerged infectious diseases. Additionally, we address technical challenges and limitations, ethical and legal considerations, and highlight opportunities for integrating genomics with other surveillance approaches. By delving into the prospects and obstacles of genomics, we can gain valuable insights into its role in mitigating the threats posed by emerging pathogens and improving global preparedness in the face of future outbreaks.
KW - emergent pathogen
KW - emerging infectious diseases
KW - genomics
KW - high-throughput DNA sequencing
KW - pathogen surveillance
UR - http://www.scopus.com/inward/record.url?scp=85180707181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85180707181&partnerID=8YFLogxK
U2 - 10.3390/biomedinformatics3040069
DO - 10.3390/biomedinformatics3040069
M3 - Review article
AN - SCOPUS:85180707181
SN - 2673-7426
VL - 3
SP - 1145
EP - 1177
JO - BioMedInformatics
JF - BioMedInformatics
IS - 4
ER -