Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects

R. J. Bollag, Q. Zhong, K. H. Ding, P. Phillips, L. Zhong, F. Qin, J. Cranford, A. L. Mulloy, R. Cameron, C. M. Isales

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


Glucose-dependent insulinotropic peptide (GIP) is a gut-derived hormone known to be important in modulating glucose-induced insulin secretion. In addition, GIP receptors are widely distributed and may have effects on multiple other tissues: fat cells, adrenal glands, endothelium and brain. We have demonstrated recently that GIP also has anabolic effects on bone-derived cells. We now demonstrate that GIP administration prevents the bone loss associated with ovariectomy. We propose that GIP plays a unique role in signaling the bone about nutrient availability, indicating the importance of the gut hormones in directing absorbed nutrients to the bone, and suggesting the concept of an 'entero-osseous axis'. Thus, GIP plays an integrative role helping coordinate efficient and targeted nutrient absorption and distribution.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalMolecular and Cellular Endocrinology
Issue number1-2
StatePublished - May 25 2001


  • Bone
  • Bone mineral density
  • GIP receptor
  • Osteoporosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology


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