Growth factor-induced therapeutic angiogenesis in the heart: Protein therapy

Brian H. Annex, Michael Simons

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations


Therapeutic angiogenesis, stimulated growth of new vasculature to compensate for tissue ischemia, remains an unfulfilled promise. After nearly a decade of trials, the development of drugs capable of stimulating revascularization of underperfused tissues remains an exciting but unrealized goal in cardiovascular therapeutics. This review will summarize experiences in therapeutic angiogenesis studies employing protein therapies and will draw conclusions based on our current understanding of biological processes of new vessel growth.

Original languageEnglish (US)
Pages (from-to)649-655
Number of pages7
JournalCardiovascular Research
Issue number3
StatePublished - Feb 15 2005
Externally publishedYes


  • Angiogenesis
  • Arteriogenesis
  • Clinical trial
  • Growth factors
  • Protein therapy

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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