Growth hormone: Independent release of big and small forms from rat pituitary in vitro

M. E. Stachura; L. A. Frohman

doi:10.1126/science.1111113

Growth hormone: Independent release of big and small forms from rat pituitary in vitro

M. E. Stachura, L. A. Frohman

Endocrinology

Research output: Contribution to journal › Article › peer-review

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Abstract

Sequential release of big and small forms of growth hormone by perifused rat pituitaries has been demonstrated by immunoprecipitation. The results suggest that either the two forms are independently synthesized and released, or that a newly synthesized molecule of big growth hormone follows one of two paths: direct release or intracellular processing through the storage compartment with conversion to small growth hormone.

Original language	English (US)
Pages (from-to)	447-449
Number of pages	3
Journal	Science
Volume	187
Issue number	4175
DOIs	https://doi.org/10.1126/science.1111113
State	Published - Jan 1 1975

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title = "Growth hormone: Independent release of big and small forms from rat pituitary in vitro",

abstract = "Sequential release of big and small forms of growth hormone by perifused rat pituitaries has been demonstrated by immunoprecipitation. The results suggest that either the two forms are independently synthesized and released, or that a newly synthesized molecule of big growth hormone follows one of two paths: direct release or intracellular processing through the storage compartment with conversion to small growth hormone.",

author = "Stachura, {M. E.} and Frohman, {L. A.}",

year = "1975",

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AU - Frohman, L. A.

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N2 - Sequential release of big and small forms of growth hormone by perifused rat pituitaries has been demonstrated by immunoprecipitation. The results suggest that either the two forms are independently synthesized and released, or that a newly synthesized molecule of big growth hormone follows one of two paths: direct release or intracellular processing through the storage compartment with conversion to small growth hormone.

AB - Sequential release of big and small forms of growth hormone by perifused rat pituitaries has been demonstrated by immunoprecipitation. The results suggest that either the two forms are independently synthesized and released, or that a newly synthesized molecule of big growth hormone follows one of two paths: direct release or intracellular processing through the storage compartment with conversion to small growth hormone.

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Growth hormone: Independent release of big and small forms from rat pituitary in vitro

Abstract

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