TY - JOUR
T1 - Heat shock proteins, thermotolerance, and their relevance to clinical hyperthermia
AU - Li, G. C.
AU - Mivechi, N. F.
AU - Weitzel, G.
N1 - Funding Information:
We wish to thank Johnson Mak for his excellent technical assistance and Ms Patricia Krechmer for typing the manuscript. This work was supported by grants NIH CA-3 1397 and CA-56909 (G. C. L.), CA-33572 (G. W.), and CA-54093 (N. F. M.).
PY - 1995
Y1 - 1995
N2 - Mammalian cells, when exposed to a non-lethal heat shock, have the ability to acquire a transient resistance to subsequent exposures at elevated temperatures, a phenomenon termed thermotolerance. The mechanism(s) for the development of thermotolerance is not well understood, but earlier experimental evidence suggests that protein synthesis may play a role in its manifestation. On the molecular level, heat shock activates a specific set of genes, so-called heat shock genes, and results in the preferential synthesis of heat shock proteins. The heat shock response, specifically the regulation, expression and functions of heat shock proteins, has been extensively studied in the past decades and has attracted the attention of a wide spectrum of investigators ranging from molecular and cell biologists to radiation and hyperthermia oncologists. There is much data supporting the hypothesis that heat shock proteins play important roles in modulating cellular responses to heat shock, and are involved in the development of thermotolerance. This review summarizes some current knowledge on thermotolerance and the functions of heat shock proteins, especially hsp70. The relationship between thermotolerance development and hsp70 synthesis in tumours and in normal tissues is examined. The possibility of using hsp70 as an indicator for thermotolerance is discussed.
AB - Mammalian cells, when exposed to a non-lethal heat shock, have the ability to acquire a transient resistance to subsequent exposures at elevated temperatures, a phenomenon termed thermotolerance. The mechanism(s) for the development of thermotolerance is not well understood, but earlier experimental evidence suggests that protein synthesis may play a role in its manifestation. On the molecular level, heat shock activates a specific set of genes, so-called heat shock genes, and results in the preferential synthesis of heat shock proteins. The heat shock response, specifically the regulation, expression and functions of heat shock proteins, has been extensively studied in the past decades and has attracted the attention of a wide spectrum of investigators ranging from molecular and cell biologists to radiation and hyperthermia oncologists. There is much data supporting the hypothesis that heat shock proteins play important roles in modulating cellular responses to heat shock, and are involved in the development of thermotolerance. This review summarizes some current knowledge on thermotolerance and the functions of heat shock proteins, especially hsp70. The relationship between thermotolerance development and hsp70 synthesis in tumours and in normal tissues is examined. The possibility of using hsp70 as an indicator for thermotolerance is discussed.
KW - Clinical hyperthermia
KW - Heat shock protein
KW - Normal tissues
KW - Thermotolerance
KW - Tumours
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U2 - 10.3109/02656739509022483
DO - 10.3109/02656739509022483
M3 - Article
C2 - 7594802
AN - SCOPUS:0029031941
SN - 0265-6736
VL - 11
SP - 459
EP - 488
JO - International Journal of Hyperthermia
JF - International Journal of Hyperthermia
IS - 4
ER -