Histone deacetylase inhibitor alleviates the neurodegenerative phenotypes and histone dysregulation in presenilins-deficient mice

Keyphrases

• Neurodegenerative 100%
• Gene-deficient Mice 100%
• Histone Deacetylase Inhibitor (HDACi) 100%
• Presenilin 100%
• Dysregulation 100%
• Histone 100%
• Double Knockout Mice 100%
• Histone Acetylation 33%
• Inflammation 22%
• Alzheimer's Disease 22%
• Forebrain 22%
• Tau Hyperphosphorylation 22%
• Memory Impairment 22%
• Neurodegeneration 11%
• Protein Level 11%
• Quantitative PCR 11%
• Molecular Mechanism 11%
• Synaptic 11%
• Alzheimer's Disease Model 11%
• Memory Formation 11%
• Dentate Gyrus 11%
• Memory Performance 11%
• Carbon Tetrachloride 11%
• Cytokine-cytokine Receptor Interaction 11%
• Immune Process 11%
• Systemic Administration 11%
• Neurogenesis 11%
• Glial Fibrillary Acidic Protein 11%
• Promising Target 11%
• Sodium Butyrate 11%
• Inflammatory Genes 11%
• Path Analysis 11%
• Treatment Withdrawal 11%
• Contextual Memory 11%
• Presenilin 2 11%
• S100A9 11%
• RNA-seq Data 11%
• Subgranular Zone 11%
• GO Analysis 11%
• Inflammation-related Proteins 11%
• Memory Rescue 11%
• Immune Cytokines 11%

Neuroscience

• Alzheimer's Disease 100%
• Presenilin 100%
• Histone Deacetylase Inhibitor 100%
• Histone 100%
• Histone Acetylation 100%
• Memory Disorder 66%
• Hyperphosphorylation 66%
• Neurodegeneration 33%
• Dentate Gyrus 33%
• Cytokine Receptor 33%
• Neurogenesis 33%
• Glial Fibrillary Acidic Protein 33%
• Presenilin 1 33%
• Butyric Acid 33%
• Presenilin 2 33%
• RNA-Seq 33%