HLA-DQB1, -DQA1, -DRB1 linkage disequilibrium and haplotype diversity in a Mestizo population from Guadalajara, Mexico

L. M. Cortes; L. M. Baltazar; F. J. Perea; M. P. Gallegos-Arreola; S. E. Flores; L. Sandoval; N. Olivares; M. G.O. Lorenz; H. Xu; S. A. Barton; R. Chakraborty; F. Rivas

doi:10.1111/j.0001-2815.2004.00202.x

HLA-DQB1, -DQA1, -DRB1 linkage disequilibrium and haplotype diversity in a Mestizo population from Guadalajara, Mexico

L. M. Cortes, L. M. Baltazar, F. J. Perea, M. P. Gallegos-Arreola, S. E. Flores, L. Sandoval, N. Olivares, M. G.O. Lorenz, H. Xu, S. A. Barton, R. Chakraborty, F. Rivas

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

HLA-DQB1, -DQA1, and -DRB1 genes were typed by polymerase chain reaction with sequence-specific primer (PCK-SSP) in 159 healthy volunteers from 32 families living in Guadalajara, Mexico. Three-locus genotype data from all family members were used to infer haplotypes in 54 unrelated individuals of the sample, from which estimate of segregating haplotype frequencies and linkage disequilibrium (LD) between loci were computed. Genotype distributions were concordant with Hardy-Weinberg expectations (HWE) for all three loci, and allele distributions were similar to the ones observed in other Latin-American populations. Of the 56 distinct three-site (DQB1-DQA1-DRB1) haplotypes observed in the sample, the five most common (i.e., with frequencies of five counts or more) were: *0302-*0301-*04, *0201-*0201- *07, *0301-*0501-*14, *0402-*0401-*08, and *0501-*0101-*01. These common three-locus haplotypes also contributed to the majority of the significant two-locus linkage disequilibria of these three sites.

Original language	English (US)
Pages (from-to)	458-465
Number of pages	8
Journal	Tissue Antigens
Volume	63
Issue number	5
DOIs	https://doi.org/10.1111/j.0001-2815.2004.00202.x
State	Published - May 2004
Externally published	Yes

Keywords

HLA class II
HLA-DQA1
HLA-DQB1
HLA-DRB1
Haplotype
Linkage disequilibrium
Mexico

ASJC Scopus subject areas

Genetics
Biochemistry
Immunology and Allergy
Immunology

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10.1111/j.0001-2815.2004.00202.x

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Cortes, L. M., Baltazar, L. M., Perea, F. J., Gallegos-Arreola, M. P., Flores, S. E., Sandoval, L., Olivares, N., Lorenz, M. G. O., Xu, H., Barton, S. A., Chakraborty, R., & Rivas, F. (2004). HLA-DQB1, -DQA1, -DRB1 linkage disequilibrium and haplotype diversity in a Mestizo population from Guadalajara, Mexico. Tissue Antigens, 63(5), 458-465. https://doi.org/10.1111/j.0001-2815.2004.00202.x

Cortes, LM, Baltazar, LM, Perea, FJ, Gallegos-Arreola, MP, Flores, SE, Sandoval, L, Olivares, N, Lorenz, MGO, Xu, H, Barton, SA, Chakraborty, R & Rivas, F 2004, 'HLA-DQB1, -DQA1, -DRB1 linkage disequilibrium and haplotype diversity in a Mestizo population from Guadalajara, Mexico', Tissue Antigens, vol. 63, no. 5, pp. 458-465. https://doi.org/10.1111/j.0001-2815.2004.00202.x

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abstract = "HLA-DQB1, -DQA1, and -DRB1 genes were typed by polymerase chain reaction with sequence-specific primer (PCK-SSP) in 159 healthy volunteers from 32 families living in Guadalajara, Mexico. Three-locus genotype data from all family members were used to infer haplotypes in 54 unrelated individuals of the sample, from which estimate of segregating haplotype frequencies and linkage disequilibrium (LD) between loci were computed. Genotype distributions were concordant with Hardy-Weinberg expectations (HWE) for all three loci, and allele distributions were similar to the ones observed in other Latin-American populations. Of the 56 distinct three-site (DQB1-DQA1-DRB1) haplotypes observed in the sample, the five most common (i.e., with frequencies of five counts or more) were: *0302-*0301-*04, *0201-*0201- *07, *0301-*0501-*14, *0402-*0401-*08, and *0501-*0101-*01. These common three-locus haplotypes also contributed to the majority of the significant two-locus linkage disequilibria of these three sites.",

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author = "Cortes, {L. M.} and Baltazar, {L. M.} and Perea, {F. J.} and Gallegos-Arreola, {M. P.} and Flores, {S. E.} and L. Sandoval and N. Olivares and Lorenz, {M. G.O.} and H. Xu and Barton, {S. A.} and R. Chakraborty and F. Rivas",

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AU - Cortes, L. M.

AU - Baltazar, L. M.

AU - Perea, F. J.

AU - Gallegos-Arreola, M. P.

AU - Flores, S. E.

AU - Sandoval, L.

AU - Olivares, N.

AU - Lorenz, M. G.O.

AU - Xu, H.

AU - Barton, S. A.

AU - Chakraborty, R.

AU - Rivas, F.

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KW - HLA-DRB1

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HLA-DQB1, -DQA1, -DRB1 linkage disequilibrium and haplotype diversity in a Mestizo population from Guadalajara, Mexico

Abstract

Keywords

ASJC Scopus subject areas

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