HPV-associated oropharyngeal Adenosquamous carcinoma with early metastatic disease detected by ctDNA

Samantha Newman; J. Harrison Cowart; Nivin Omar; Elizabeth Martin; J. Kenneth Byrd

doi:10.1016/j.oraloncology.2023.106526

HPV-associated oropharyngeal Adenosquamous carcinoma with early metastatic disease detected by ctDNA

Samantha Newman, J. Harrison Cowart, Nivin Omar, Elizabeth Martin, J. Kenneth Byrd

Research output: Contribution to journal › Letter › peer-review

Abstract

Adenosquamous Carcinoma is a rare, aggresssive variant of squamous cell carcinoma that may HPV-driven in the oropharynx. Although it is reported to behave similar to HPV-related squamous cell carcinoma, the literature is very limited for this disease. We present a case of early T and N stage HPV + adenosquamous carcinoma of the tonsil that metastasized immediately following surgery and adjuvant therapy despite only having microscopic nodal burden. Circulating tumor DNA (ctDNA) was instrumental in recognizing and salvaging metastatic disease early with radiation.

Original language	English (US)
Article number	106526
Journal	Oral Oncology
Volume	145
DOIs	https://doi.org/10.1016/j.oraloncology.2023.106526
State	Published - Oct 2023
Externally published	Yes

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oraloncology.2023.106526

Cite this

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title = "HPV-associated oropharyngeal Adenosquamous carcinoma with early metastatic disease detected by ctDNA",

abstract = "Adenosquamous Carcinoma is a rare, aggresssive variant of squamous cell carcinoma that may HPV-driven in the oropharynx. Although it is reported to behave similar to HPV-related squamous cell carcinoma, the literature is very limited for this disease. We present a case of early T and N stage HPV + adenosquamous carcinoma of the tonsil that metastasized immediately following surgery and adjuvant therapy despite only having microscopic nodal burden. Circulating tumor DNA (ctDNA) was instrumental in recognizing and salvaging metastatic disease early with radiation.",

author = "Samantha Newman and Cowart, {J. Harrison} and Nivin Omar and Elizabeth Martin and Byrd, {J. Kenneth}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = oct,

doi = "10.1016/j.oraloncology.2023.106526",

language = "English (US)",

volume = "145",

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issn = "1368-8375",

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TY - JOUR

T1 - HPV-associated oropharyngeal Adenosquamous carcinoma with early metastatic disease detected by ctDNA

AU - Newman, Samantha

AU - Cowart, J. Harrison

AU - Omar, Nivin

AU - Martin, Elizabeth

AU - Byrd, J. Kenneth

PY - 2023/10

Y1 - 2023/10

N2 - Adenosquamous Carcinoma is a rare, aggresssive variant of squamous cell carcinoma that may HPV-driven in the oropharynx. Although it is reported to behave similar to HPV-related squamous cell carcinoma, the literature is very limited for this disease. We present a case of early T and N stage HPV + adenosquamous carcinoma of the tonsil that metastasized immediately following surgery and adjuvant therapy despite only having microscopic nodal burden. Circulating tumor DNA (ctDNA) was instrumental in recognizing and salvaging metastatic disease early with radiation.

AB - Adenosquamous Carcinoma is a rare, aggresssive variant of squamous cell carcinoma that may HPV-driven in the oropharynx. Although it is reported to behave similar to HPV-related squamous cell carcinoma, the literature is very limited for this disease. We present a case of early T and N stage HPV + adenosquamous carcinoma of the tonsil that metastasized immediately following surgery and adjuvant therapy despite only having microscopic nodal burden. Circulating tumor DNA (ctDNA) was instrumental in recognizing and salvaging metastatic disease early with radiation.

UR - http://www.scopus.com/inward/record.url?scp=85165562872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85165562872&partnerID=8YFLogxK

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DO - 10.1016/j.oraloncology.2023.106526

M3 - Letter

C2 - 37482044

AN - SCOPUS:85165562872

SN - 1368-8375

VL - 145

JO - Oral Oncology

JF - Oral Oncology

M1 - 106526

ER -

HPV-associated oropharyngeal Adenosquamous carcinoma with early metastatic disease detected by ctDNA

Abstract

ASJC Scopus subject areas

UN SDGs

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