Abstract
A propeptide converting enzyme capable of producing somatostatin-14 has been identified and partially characterized from anglerfish pancreatic islets. Results from N-terminal protein sequence analysis indicate that this enzyme is a member of the kex2/furin/PC family. This observation provides strong corroborative evidence that the kex2/ furin/PC protease family is involved in propeptide conversion. Comparison of the obtained protein sequence with the cDNA sequence of mammalian PC2 also suggests that the active enzyme is derived from a precursor by cleavage at a site containing four consecutive basic amino acids.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2263-2265 |
| Number of pages | 3 |
| Journal | Endocrinology |
| Volume | 129 |
| Issue number | 4 |
| State | Published - Oct 1991 |
| Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology